Cerovive (NXY-059) is a novel nitrone, shows efficacious neuroprotective effects that prevents ischemic damage by trapping free radicals. Used as a spin-trap agent. It is a clinically tested antioxidant and depicts potency against Ischemic stress, Neuroprotection.
A free radical trapping compound
Free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant.
Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v. in rabbits; 30-60 mg/kg plus 30-60 mg/kg/h i.v. or 50 mg/kg plus 8.8 mg/kg/h s.c. in rats; 28 mg/kg plus 16 mg/kg/h i.v. in monkeys), OKN-007 (HPN-07, NXY-059) is an orally available α-phenyl-tert-butylnitrone (PBN) derivative that is also shown to exhibit sulfatase 2 (SULF2) inhibitory activity and anticancer efficacy both in cultures (effective conc. 170-200 μM in Huh7 heptoma cultures) and in several rodent glioma models in vivo (C6, RG2, and GL261; 75 mg/kg/day for rats and 168 mg/kg/day for mice via drinking water).
Disufenton sodium (28 mg/kg, iv and osmotic pump for 48 h) reduces cerebral infarction volume and improves behavioral dysfunction in marmoset permanent middle cerebral artery occlusion (pMCAO) models[2].
| Animal Model: | Marmoset pMCAO models[2] |
| Dosage: | 60 mg/kg |
| Administration: | 28 mg/kg for iv, 16 mg/kgh for 48 h via osmotic pump |
| Result: | Ameliorated ischemic brain injury. |
[1] kuroda s1, tsuchidate r, smith ml, maples kr, siesjö bk.
![1,3-Benzenedisulfonic acid, 4-[[(1,1-dimethylethyl)oxidoimino]methyl]-,disodium salt Structure](/CAS/GIF/168021-79-2.gif)
