1,3-BENZENEDISULFONIC ACID, 4-[[(1,1-DIMETHYLETHYL)OXIDOIMINO]METHYL]-,DISODIUM SALT

Uses

Cerovive (NXY-059) is a novel nitrone, shows efficacious neuroprotective effects that prevents ischemic damage by trapping free radicals. Used as a spin-trap agent. It is a clinically tested antioxidant and depicts potency against Ischemic stress, Neuroprotection.

Uses

A free radical trapping compound

Uses

Cerovive (NXY-059) is a novel nitrone, shows efficacious neuroprotective effects that prevents ischemic damage by trapping free radicals. Neuroprotectant.

Biological Activity

Free radical trapping agent. Reduces infarct size and preserves brain function in several animal models of acute ischemic stroke. Neuroprotectant.

Biochem/physiol Actions

Originally characterized for its NO-mimicking activity in preventing peroxynitrite formation and in vivo neuroprotective efficacy in animal models of cerebral ischemia (100 mg/kg i.v. in rabbits; 30-60 mg/kg plus 30-60 mg/kg/h i.v. or 50 mg/kg plus 8.8 mg/kg/h s.c. in rats; 28 mg/kg plus 16 mg/kg/h i.v. in monkeys), OKN-007 (HPN-07, NXY-059) is an orally available α-phenyl-tert-butylnitrone (PBN) derivative that is also shown to exhibit sulfatase 2 (SULF2) inhibitory activity and anticancer efficacy both in cultures (effective conc. 170-200 μM in Huh7 heptoma cultures) and in several rodent glioma models in vivo (C6, RG2, and GL261; 75 mg/kg/day for rats and 168 mg/kg/day for mice via drinking water).

References

[1] kuroda s1, tsuchidate r, smith ml, maples kr, siesjö bk.