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Amobarbital

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Amobarbital Basic information
Amobarbital Chemical Properties
  • Melting point:156-158°C
  • Boiling point:367.89°C (rough estimate)
  • Density 1.1376 (rough estimate)
  • refractive index 1.4620 (estimate)
  • Flash point:9℃
  • storage temp. -20°C
  • pka8.0(at 25℃)
  • color Slightly bitter crystals or leaflets from water oralc
  • Water Solubility <0.1 g/100 mL at 18.5 ºC
  • Stability:Stable. Incompatible with strong oxidizing agents. Hygroscopic.
  • CAS DataBase Reference57-43-2(CAS DataBase Reference)
  • NIST Chemistry ReferenceBarbituric acid, 5-ethyl-5-isoamyl-(57-43-2)
  • EPA Substance Registry SystemAmobarbital (57-43-2)
Safety Information
MSDS
Amobarbital Usage And Synthesis
  • Chemical PropertiesCrystalline Solid
  • OriginatorHypnotal,Pharmacal
  • UsesControlled substance (depressant). Sedative, hypnotic
  • UsesSedative, hypnotic. Controlled substance (depressant).
  • UsesAmobarbital for binding at complex I to inhibit mitochondrial electron transport. Amobarbital is regulated as a schedule II compound in the United States and intended only for forensic and research purposes.
    This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO17025 and Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.
  • DefinitionChEBI: A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by a 3-methylbutyl and an ethyl group at position 5. Amobarbital has been shown to exhibit sedative and hy notic properties.
  • Manufacturing ProcessBy interaction of malonic acid diethyl ester with sodium ethylate (molar ratio 1:1) and then with ethyl bromide (molar ratio 1:1) was prepared ethylmalonic acid diethyl ester. From ethylmalonic acid diethyl ester and sodium ethylate (molar ratio 1:1) and then with isopentylbromide was synthesized α-ethyl-α- isopentylmalonic acid diethyl ester. By condensation of α-ethyl-α- isopentylmalonic acid diethyl ester with urea in the presence of sodium ethylate was obtained ethyl-isopentylbarbituric acid.
  • brand nameAmytal Sodium (Lilly); Talamo (Marion Merrell Dow);Altinal;Alupent-sed;Ambese-la;Amobell;Amsal;Amycal;Amydorm;Amylbarb;Amylobeta;Analgilasa;Appenil;Asthmin;Beatol;Bludex;Calavon;Cuaot;Dexaspan;Dexital;Ergo-lonarid;Estimal;Etamyl;Ifenin;Isoamitil sedante;Isobec;Jalonac;Lonarid n;Medi-trol;Mudeka;Mylodorm sustrel;N 8;Neur-amyl;Novambobarb;Novogen;Obe_slim;Placidel;Protasma;Sedo-rythmodan;Sy-dexam;Transital.
  • Therapeutic FunctionHypnotic, Antiepileptic
  • World Health Organization (WHO)Amobarbital is an intermediate-acting barbiturate which is controlled under Schedule III of the 1971 Convention on Psychotropic Substances. See WHO comment for barbiturates. (Reference: (UNCPS3) United Nations Convention on Psychotropic Substances (III), , , 1971)
  • General DescriptionWhite crystalline solid with no odor and a slightly bitter taste.
  • Air & Water ReactionsAmobarbital is hygroscopic . Insoluble in water.
  • Reactivity ProfileAmines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
  • HazardMay be a habit forming drug of abuse.
  • Fire HazardFlash point data for Amobarbital are not available, however, Amobarbital is probably combustible.
  • Safety ProfileA poison by ingestion,intravenous, intraperitoneal, and subcutaneous routes. Seealso BARBITURATES. When heated to decomposition itemits toxic fumes of NOx.
Amobarbital Preparation Products And Raw materials
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