PKUMDL-LC-101-D04

PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4).¹ It increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay and at 61 μM in wild-type, but not Gpx4^-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death.

1. Li, C., Deng, X., Zhang, W., et al. Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4 J. Med. Chem. 62(1),266-275(2019).