Basic information Description Safety Related Supplier


Basic information Description Safety Related Supplier
BAPTA-AM Basic information
BAPTA-AM Chemical Properties
  • Melting point:86-90°C
  • Boiling point:796.1±60.0 °C(Predicted)
  • Density 1.350±0.06 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility Soluble in chloroform, dimethyl sulfoxide
  • form powder
  • pka1.69±0.50(Predicted)
  • color White
  • λmax287 nm
  • BRN 7458534
  • Stability:Light Sensitive
  • Biological ApplicationsCalcium indicators; treating cancer,chronic bacterial infection,glaucoma,ocular hypertension,HIV-associated conditions,infectious diseases,neurodegenerative disorders,neurological conditions,psychiatric conditions
  • CAS DataBase Reference126150-97-8(CAS DataBase Reference)
Safety Information
BAPTA-AM Usage And Synthesis
  • DescriptionBAPTA-AM is a selective, membrane-permeable calcium chelator.
  • Chemical PropertiesOff-White to Light Yellow Solid
  • UsesA cell permeable derivative of BAPTA which is widely used as an intracellular calcium sponge. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9
  • UsesBAPTA-AM is a lipophilic diester of BAPTA used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9
  • UsesA membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2+ stores.
  • UsesBAPTA is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons. BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases. It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling. It can also be used in animals. BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).
  • General Description
    BAPTA-AM inhibits free radical-mediated toxicity, enhances apoptosis in non-neuronal cells and protects neurons from ischemic damage. It regulates ion channels and blocks neuronal Ca2+-activated K+?channel currents. BAPTA-AM maintains intracellular Ca2+ homeostasis.
  • Biological ActivitySelective calcium chelator that is the cell-permeable analog of BAPTA (Cat No. 2786 ). Blocks hK v 1.5, hERG and hK v 1.3 channels (K i values are 1.23, 1.30 and 1.45 μ M respectively). Displays antithrombotic activity in vitro .
  • Biochem/physiol ActionsSelective chelator of intracellular Ca2+ stores.
BAPTA-AM(126150-97-8)Related Product Information
  • Company Name:Maya High Purity Chemicals Gold
  • Tel:+86 (573) 82222445 (0)18006601000 QQ:452520369
  • Products Intro:Product Name:BAPTA-AM
    Purity:98% Package:25g;100g
  • Company Name:Hefei NaNo Biological Technology Co., Ltd. Gold
  • Tel:18010855303
    Purity:99% Package:1g;25g;50g;100g
  • Company Name:Shanghai Race Chemical Co., Ltd. Gold
  • Tel:86-021-54933292
  • Products Intro:Product Name:BAPTA-AM
    Purity:99% Package:1g,2g,5g,25g, 50g,100g Remarks:
  • Company Name:Shanghai Tube Pharmaceutical Co., Ltd. Gold
  • Tel:18017892860 021-54338626-
  • Products Intro:Product Name:BAPTA-AM
    Purity:99% Package:1g,2g,5g,25g, 50g,100g
  • Company Name:J & K SCIENTIFIC LTD.
  • Tel:400-666-7788 010-82848833-
  • Products Intro:Product Name:BAPTA, AM
    Purity:95.0%(LC) Package:25MG