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ROSCOVITINE

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ROSCOVITINE Basic information
ROSCOVITINE Chemical Properties
  • Melting point:106~107℃
  • Boiling point:577.5±60.0 °C(Predicted)
  • Density 1.3
  • storage temp. −20°C
  • pka14.56±0.10(Predicted)
  • form White to off-white solid
  • InChIKeyBTIHMVBBUGXLCJ-OAHLLOKOSA-N
  • CAS DataBase Reference186692-46-6(CAS DataBase Reference)
Safety Information
  • Safety Statements 22-24/25
  • WGK Germany 3
  • HS Code 29335990
MSDS
ROSCOVITINE Usage And Synthesis
  • UsesRoscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). Roscovitine has been found to produce apoptosis in treated cancerous cells of non-small cell lung cancer (NSCLC) and other cancers. Studies show that Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. Roscovitine maybe useful in the treatment of non-small cell lung c ancer (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation disorders.
  • DefinitionChEBI: 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.
  • Anticancer ResearchRoscovitine a derivative of olomoucine which is isolated from Raphanus sativus isunder clinical trials (Shoeb 2006).
ROSCOVITINE(186692-46-6)Related Product Information
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