ChemicalBook > Product Catalog > Biochemical Engineering > Inhibitors > Cell Cycle > CDK inhibitors > ROSCOVITINE
ROSCOVITINE
- Product Name:ROSCOVITINE
- CAS:186692-46-6
- MF:C19H26N6O
- MW:354.45
- EINECS:
- Mol File:186692-46-6.mol
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ROSCOVITINE Chemical Properties
- Melting point:106～107℃
- Boiling point:577.5±60.0 °C(Predicted)
- Density 1.3
- storage temp. −20°C
- pka14.56±0.10(Predicted)
- form White to off-white solid
- InChIKeyBTIHMVBBUGXLCJ-OAHLLOKOSA-N
- CAS DataBase Reference186692-46-6(CAS DataBase Reference)
- Safety Statements 22-24/25
- WGK Germany 3
- HS Code 29335990
- Language:EnglishProvider:SigmaAldrich
ROSCOVITINE Usage And Synthesis
- UsesRoscovitine is a potent and selective inhibitor of cyclin-dependent kinases (CDKs). Roscovitine has been found to produce apoptosis in treated cancerous cells of non-small cell lung cancer (NSCLC) and other cancers. Studies show that Roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle. Roscovitine maybe useful in the treatment of non-small cell lung c ancer (NSCLC), leukemia, HIV infection, herpes simplex infection, and the mechanisms of chronic inflammation disorders.
- DefinitionChEBI: 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.
- Anticancer ResearchRoscovitine a derivative of olomoucine which is isolated from Raphanus sativus isunder clinical trials (Shoeb 2006).
- BML-259 1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Selumetinib Alisertib (MLN8237) Dasatinib PD 0332991 HCl (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol PD0332991 Isethionate NS-398 ROSCOVITINE, 99+% RS-ROSCOVITINE 98% (HPLC) (R)-ROSCOVITINE, >95% ROSCOVITINE, IMMOBILIZED S-ROSCOVITINE 98% (HPLC),ROSCOVITINE, (S)-ISOMER,(S)-ROSCOVITINE OLOMOUCINE II SELICICLIB (S)-ROSCOVITINE ROSCOVITINE
ROSCOVITINESupplierMore
- Company Name:Shanghai EFE Biological Technology Co., Ltd. Gold
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- Email:info@efebio.com
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- Email:sales@skychemical.com
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- Email:3358272972@qq.com
- Company Name:Changzhou Xuanye Technology Co., Ltd Gold
- Tel:15195022192
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- Company Name:Shanghai Boyle Chemical Co., Ltd.
- Tel:
- Email:sales@boylechem.com