Biotin-tat (47-57)

Biotin-TAT (47-57), a biotin tagged TAT, is a transactivator of transcription. Biotin-TAT (47-57) is one of the most widely used protein transduction domains (PTDs) into different primary cells is ATP- and temperature-dependent, indicating the involvement of endocytosis[1][2].

[1] Chen Sun, et al. Intracellular tracking of single native molecules with electroporation-delivered quantum dots. Anal Chem. 2014 Nov 18;86(22):11403-9. DOI:10.1021/ac503363m
[2] Jean Philippe Richard, et al. Cellular uptake of unconjugated TAT peptide involves clathrin-dependent endocytosis and heparan sulfate receptors. J Biol Chem. 2005 Apr 15;280(15):15300-6. DOI:10.1074/jbc.M401604200