Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride

Product NameMn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride
CAS55266-18-7
MFC48H28ClMnN4O8
MW879.148969
EINECS
MOL File55266-18-7.mol

Chemical Properties

storage temp.	-20C
solubility	Soluble in 0.1M NaOH
form	Brown solid
color	Black
Stability	Stable for 2 years from date of purchase as supplied. Solutions in 0.1M NaOH may be stored at -20° for up to 1 month.
InChIKey	XHVDAQLNUQLQKW-PTJHDCLZSA-K
SMILES	[Mn]1([n]2c3c(c5nc(c(c7[n]1c(c(c9nc(c(c2cc3)c%10ccc(cc%10)C(=O)O)cc9)c8ccc(cc8)C(=O)O)cc7)c6ccc(cc6)C(=O)O)cc5)c4ccc(cc4)C(=O)O)Cl

Safety Information

WGK Germany	WGK 1
Storage Class	11 - Combustible Solids

Usage And Synthesis

Description

MnTBAP (55266-18-7) is a superoxide dismutase (SOD) mimetic. Potent peroxynitrite scavenger but does not scavenge nitric oxide.

Uses

MnTBAP chloride is a cell permeable superoxide dismutase mimetic and peroxynitrite scavenger.

General Description

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC₅₀ ~40 μM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).

Biochem/physiol Actions

Cell permeable: yes

in vivo

MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice^[1].

Animal Model:	C57BL/6J mice with 5/6 nephrectomy (Nx)^[1]
Dosage:	10mg/kg
Administration:	IP; three times per week for twelve weeks
Result:	Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.

IC 50

NFκB

References

[1] CSABA SZABÓ Andrew L S Brian J Day. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger[J]. FEBS Letters, 1996, 381 1-2: 82-86. DOI:10.1016/0014-5793(96)00087-7
[2] K M FAULKNER I F S I Liochev. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo.[J]. The Journal of Biological Chemistry, 1994, 269 38: 23471-23476.

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