Description
MnTBAP (55266-18-7) is a superoxide dismutase (SOD) mimetic. Potent peroxynitrite scavenger but does not scavenge nitric oxide.
Uses
MnTBAP chloride is a cell permeable superoxide dismutase mimetic and peroxynitrite scavenger.
General Description
Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC
50 ~40 μM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No.
309825) by peroxynitrite, but does not scavenge nitric oxide (NO).
Biochem/physiol Actions
Cell permeable: yes
in vivo
MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice[1].
| Animal Model: | C57BL/6J mice with 5/6 nephrectomy (Nx)[1] |
| Dosage: | 10mg/kg |
| Administration: | IP; three times per week for twelve weeks |
| Result: | Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.
|
References
[1] CSABA SZABÓ Andrew L S Brian J Day. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger[J]. FEBS Letters, 1996, 381 1-2: 82-86. DOI:
10.1016/0014-5793(96)00087-7[2] K M FAULKNER I F S I Liochev. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo.[J]. The Journal of Biological Chemistry, 1994, 269 38: 23471-23476.
