Mn(III) Meso-Tetra (4-carboxyphenyl) porphine chloride

Description

MnTBAP (55266-18-7) is a superoxide dismutase (SOD) mimetic. Potent peroxynitrite scavenger but does not scavenge nitric oxide.

Uses

MnTBAP chloride is a cell permeable superoxide dismutase mimetic and peroxynitrite scavenger.

General Description

Cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC₅₀ ~40 μM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).

Biochem/physiol Actions

Cell permeable: yes

References

1) Szabo et al. (1996), Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial resporation in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger; FEBS Lett., 381 82 2) Faulkner et al. (1994), Stable MN(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo; J. Biol. Chem., 269 23471