Ferrostatin-1 (Fer-1)

Ferrostatin-1 (347174-05-4) inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death.1Potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices.1Blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells.2Ferrostatin-1 inhibits oxidative lipid damage and cell death in diverse disease models3 and prevents apoptosis of renal proximal tubular cells induced by reactive oxygen species4.

Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis.

ChEBI: Ferrostatin-1 is an ethyl ester resulting from the formal condensation of the carboxy group of 3-amino-4-(cyclohexylamino)benzoic acid with ethanol. It is a potent inhibitor of ferroptosis, a distinct non-apoptotic form of cell death caused by lipid peroxidation. It is also a radical-trapping antioxidant and has the ability to reduce the accumulation of lipid peroxides and chain-carrying peroxyl radicals. It has a role as a ferroptosis inhibitor, a radiation protective agent, an antioxidant, a radical scavenger, an antifungal agent and a neuroprotective agent. It is a substituted aniline, an ethyl ester and a primary arylamine.

Ferrostatin-1 is an active radical-trapping antioxidant that traps peroxyl radicals, and thus serves as a potential inhibitor of ferroptosis. Ferroptosis is considered as regulated necrosis, which differs from apoptosis and autophagy. Ferrostatin-1 is known to show protective effects against Huntington′s disease and also prevents neurotoxicity induced by glutamate in cellular models.

Store at +4°C

[1] SCOTT J DIXON. Ferroptosis: an iron-dependent form of nonapoptotic cell death.[J]. Cell, 2012, 149 5: 1060-1072. DOI:10.1016/j.cell.2012.03.042
[2] CHRISTOPHE LOUANDRE. Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib[J]. International Journal of Cancer, 2013, 133 7: 1732-1742. DOI:10.1002/ijc.28159
[3] RACHID SKOUTA. Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models[J]. Journal of the American Chemical Society, 2014, 136 12: 4551-4556. DOI:10.1021/ja411006a
[4] GRAZYNA NOWAK  Ruben M  Sridharan Soundararajan. Protein kinase C-α interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells.[J]. American Journal of Physiology-renal Physiology, 2013, 305 5: F764-76. DOI:10.1152/ajprenal.00061.2013