Fluphenazine Decanoate is used in psychotropic drug treatments like those relating to schizophrenia. Antipsychotic.
ChEBI: Fluphenazine decanoate is the prodrug of fluphenazine, an antipsychotic drug used for the symptomatic management of psychosis in patients with schizophrenia. It has a role as a phenothiazine antipsychotic drug, a prodrug and a dopaminergic antagonist. It is a member of phenothiazines, a decanoate ester, an organofluorine compound and a N-alkylpiperazine. It is functionally related to a fluphenazine.
AntipsychoticSchizophrenia and other psychoses
Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: increased risk of convulsions with
tramadol; enhanced hypotensive and sedative effects
with opioids. Anti-arrhythmics: increased risk of ventricular
arrhythmias with anti-arrhythmics that prolong
the QT interval; increased risk of ventricular
arrhythmias with amiodarone and dronedarone -
avoid; increased risk of ventricular arrhythmias with
disopyramide.Antibacterials: increased risk of ventricular
arrhythmias with delamanid and moxifloxacin -
avoid Antidepressants: increased risk of ventricular
arrhythmias with tricyclics, citalopram, escitalopram;
possible increased risk of convulsions with
vortioxetineAntiepileptics: antagonises anticonvulsant effect.Antimalarials: increased risk of ventricular
arrhythmias with artenimol with piperaquine and
artemether/lumefantrine - avoid.Antipsychotics: increased risk of ventricular
arrhythmias with droperidol, pimozide and
risperidone - avoid; avoid use of depot formulations
with clozapine (cannot be withdrawn quickly if
neutropenia occurs).Antivirals: increased risk of ventricular arrhythmias
with saquinavir - avoid; concentration possibly
increased with ritonavir.Anxiolytics and hypnotics: increased sedative effectsAtomoxetine: increased risk of ventricular
arrhythmias.Beta-blockers: enhanced hypotensive effect;
increased risk of ventricular arrhythmias with sotalolCytotoxics: increased risk of ventricular arrhythmias
with arsenic trioxideDiuretics: enhanced hypotensive effect.Lithium: increased risk of extrapyramidal side effects
and possibly neurotoxicity.Pentamidine: increased risk of ventricular
arrhythmias - avoid.Avoid with drugs that prolong the QT interval.
The cytochrome P450 isoenzyme CYP2D6 is involved in
fluphenazine metabolism.
