N-fluorenemethyloxycarbonyl-dodecyl polyethylene glycol-carboxylic acid was used as a linker for preparing PEG peptide surfaces, serving as an attractive platform for developing peptide microarrays.
N-fluorenemethyloxycarbonyl-dodecyl polyethylene glycol-carboxylic acid is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes as well as in chemical and pharmaceutical synthesis processes.
Fmoc-NH-PEG12-CH2CH2COOH (also known as Fmoc-NH-PEG12-propionic acid) is a protected form of propionic acid modified with Fmoc (9-FLUORENYLME- THOXYCARBONYL) and PEG12 (polyethylene glycol 12). It is useful in the peptide synthesis and biomolecules synthesis. For example, it can be used for tether peptides to proteins or other large biomolecules (such as nucleic acids). The attachment of the hydrophobic peptide, NH2-PEG12 can effectively reduce aggregation.
Viscous, colorless to yellow liquid
FMoc-NH-PEG12-CH2CH2COOH (CAS 756526-01-9), also known as Fmoc-N-amido-PEG12-Acid, Fmoc-NH-PEG12-CH₂CH₂COOH and (Fmoc-amino)-PEG12-C₂-carboxylic acid, is a high-purity, heterobifunctional, monodisperse PEG linker. This compound possesses an Fmoc-protected amine group at one end and a carboxyl group at the other, and is primarily used as a bioconjugation reagent in solid-phase peptide synthesis.
reaction type: Pegylations
https://www.aapptec.com/fmocnhpeg12propionic-acid-i-396.html
Strømgaard, Kristian, A. Bach, and K. B. Nissen. "FATTY ACID DERIVATIVES OF DIMERIC INHIBITORS OF PSD-95.", WO/2015/078477. 2015.
Masayasu Kuwahara, et al. "Synthesis of oxy-peptide nucleic acids with mixed sequences." Nucleic acids symposium series 42.42(1999):31.
