Fmoc-N-amido-PEG8-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Fmoc-NH-PEG8-CH2CH2COOH is used in synthesis of protein-antiviral compound conjugates.
Fmoc-NH-PEG8-CH₂CH₂COOH (CAS 756526-02-0) is a high-purity, degradable ADC linker that can be used in the synthesis of antibody-drug conjugates (ADCs). Its synonyms include Fmoc-N-amido-PEG8-acid, Fmoc-NH-PEG8-COOH, Fmoc-PEG8-propionic acid and Fmoc-NH-PEG8-propionic acid, amongst others.
Fmoc-NH-PEG8-CH₂CH₂COOH is irritating to humans. Contact may cause skin irritation and serious eye damage or irritation.
reaction type: Pegylations
