Biotin-PEG4-NHS is an amine reactive reagent that contains biotin linked via a four-unit PEG spacer to N-hydroxysuccinimide (NHS), which facilitates the coupling of biotin to primary amines. Biotin-PEG4-NHS has been used in the biotinylation of proteins and antibodies.
Biotin-PEG4-NHS ester is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
reagent type: cross-linking reagent
reaction type: Biotinylations
reactivity: amine reactive
reagent type: linker
[1] Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. DOI:
10.1038/nchembio.2329