基本属性 生物活性靶点体外研究体内研究 用途与合成方法 N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺 价格(试剂级) 供应商 供应信息 相关产品
网站主页  化工产品目录 生物化工  抑制剂  细胞凋亡(Apoptosis)  Bcl-2 抑制剂  N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺

N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺

N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺

英文名称:TW-37
CAS号:877877-35-5
分子式:C33H35NO6S
分子量:573.7
EINECS号:
Mol文件:877877-35-5.mol
N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺 结构式

N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺 性质

沸点 723.7±60.0 °C(Predicted)
密度 1.280
储存条件 Store at -20°C
溶解度 不溶于水; DMSO 中≥19.75 mg/mL;温和加热和超声波下,乙醇中≥3.41 mg/mL
形态 结晶固体
酸度系数(pKa) 7.86±0.50(Predicted)

N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺 用途与合成方法

TW-37 是一种有效的 Bcl-2 抑制剂,作用于 Mcl-1,Bcl-2 和 Bcl-xL,Ki 值分别为 260,290 和 1110 nM。

Mcl-1

260 nM (Ki)

Bcl-2

290 nM (Ki)

Bcl-xL

1110 nM (Ki)

TW-37 (TW37) is a novel nonpeptide small-molecule inhibitor designed using a structure-based design strategy. TW-37 targets the BH3-binding groove in Bcl-2 where proapoptotic Bcl-2 proteins, such as Bak, Bax, and Bid bind. In fluorescence polarization-based binding assays using recombinant Bcl-2 and Bcl-xL proteins, TW-37 binds to Bcl-2 and Bcl-xL with K i values of 290 and 1110 nM, respectively. TW-37 has an IC 50 of 1.8 μM for endothelial cells but shows no cytotoxic effects for fibroblasts at concentrations up to 50 μM. The mechanism of TW-37-induced endothelial cell death is apoptosis, in a process mediated by mitochondrial depolarization and activation of caspase-9 and caspase-3. The effect of TW-37 on endothelial cell apoptosis is not prevented by coexposure to the growth factor milieu secreted by tumor cells. Inhibition of the angiogenic potential of endothelial cells (i.e., migration and capillary sprouting assays) and expression of the angiogenic chemokines CXCL1 and CXCL8 are accomplished at subapoptotic TW-37 concentrations (0.005-0.05 μM). TW-37 is a potent Bcl-2 and Mcl-1 inhibitor. In fluorescence polarization-based binding assays using recombinant Bcl-2, Bcl-xL, and Mcl-1 proteins, TW-37 binds to Bcl-2, Bcl-xL, and Mcl-1 with K i values of 290, 1,110 and 260 nM, respectively.

A murine model of humanized vasculature is used to investigate the biological effect of TW-37 (TW37) on human microvascular endothelial cell in vivo. Using this model, a significant decrease is observed in total blood vessel number (P<0.05) comparing both 3 and 30 mg/kg TW-37 against vehicle control. In addition to reduction in total number of blood vessels, an unusual number of occluded vessels are occurring in the treated groups. The levels of vessel occlusion are assessed by counting completely blocked vessels and determining their number as a percentage of total vessel number. TW-37 concentration mediates a significant increase in the number of occluded vessels when compared with control.

N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺 价格(试剂级)

更新日期 产品编号 产品名称 CAS号 包装 价格
2024-01-25 HY-12020 1 mg 320
2024-01-25 HY-12020 5 mg 800

N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺供应商 更多

上海楼岚生物科技有限公司
黄金产品
联系电话:021-52996696,15000506266 15000506266
产品介绍:
英文名称:TW37
CAS:877877-35-5
纯度:>98%
包装信息:2g
备注:2g
深圳市凯米克生物科技有限公司
黄金产品 现货
联系电话:18964309092 18964309092
产品介绍:
中文名称:N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺
英文名称:TW-37
CAS:877877-35-5
纯度:98%+HPLC
包装信息:1g;5g;10g;50g;100g
库存量:>20g
现货日期:2024/3/18 12:10:40
河南阿尔法化工有限公司
现货
联系电话:0371-55013243 15324716602
产品介绍:
中文名称:N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苄基)苯甲酰胺
英文名称:N-[4-(2-tert-Butylphenylsulfonyl)phenyl]-2,3,4-trihydroxy-5-(2-isopropylbenzyl)benzamide
CAS:877877-35-5
纯度:98%
包装信息:g;kg
备注:可按需分装,高校、科研单位可先发货后付款,欢迎询价!QQ:2853979810 电话(同微信):15324716602
库存量:1g
现货日期:2024/3/25 17:44:24
武汉易泰科技有限公司上海分公司
联系电话:821-50328103-801 18930552037
产品介绍:
中文名称:N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺
英文名称:TW 37;N-[4-[[2-(1,1-DiMethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-Methylethyl)phenyl]Methyl]benzaMide
CAS:877877-35-5
纯度:99% HPLC
包装信息:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
上海佰世凯化学科技有限公司
联系电话:021-20908456
产品介绍:
英文名称:TW-37
CAS:877877-35-5
备注:C14300

最新发布供应信息

Bcl-2,Bcl-xL和Mcl-1抑制剂(TW-37)
上海泽叶生物科技有限公司 2024-03-28
TW-37 877877-35-5
成都彼样生物科技有限公司 2024-03-26

"N-[4-(2-叔丁基苯磺酰基)苯基]-2,3,4-三羟基-5-(2-异丙基苯基甲基)苯甲酰胺"相关产品信息