Basic information Safety Related Supplier
ChemicalBook >  Product Catalog >  Biochemical Engineering >  Plant extracts >  Forskolin

Forskolin

Basic information Safety Related Supplier
Forskolin Basic information
Forskolin Chemical Properties
  • Melting point:282-232 °C
  • Boiling point:520℃
  • alpha D25 -26.19° (c = 1.68 in CHCl3)
  • Density 1.23
  • refractive index 1.5300 (estimate)
  • Flash point:172℃
  • storage temp. room temp
  • solubility DMSO: 5 mg/mL stable at least 6 months at room temperature
  • form powder
  • pka11.00±0.70(Predicted)
  • color off-white
  • Water Solubility Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water.
  • λmax305nm(lit.)
  • Merck 14,2476
  • BRN 1692716
  • InChIKeyOHCQJHSOBUTRHG-KGGHGJDLSA-N
  • CAS DataBase Reference66575-29-9
Safety Information
  • Hazard Codes Xn
  • Risk Statements 21
  • Safety Statements 22-36/37
  • WGK Germany 3
  • RTECS QL6150000
  • 10-21
  • HS Code 29329990
MSDS
Forskolin Usage And Synthesis
  • Chemical PropertiesColorless Crystalline Solid
  • UsesForskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP.
  • Usesglucocorticoid, antiinflammatory
  • Usesadenylate cyclase activator, antiglaucoma, hypotensive, vasodilator
  • UsesCyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.[Cayman Chemical]
  • UsesAn adenylate cyclase activator and MAP kinase inhibitor
  • UsesIn purification of adenylate cyclase.
  • Biological ActivityCell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Also available as part of the PKA Tocriset™ .
  • Purification MethodsIt is an antihypertensive, a positive ionotropic, a platelet aggregation inhibitor, and it has adenylate cyclase activating properties [Chem Abstr 89 244150 1978, de Souza et al. Med Res Rev 3 201 1983, X-ray: Tandon et al. Indian J Chem 15B 880 1977]. [Beilstein 18/5 V 55.]
Forskolin(66575-29-9)Related Product Information
ForskolinSupplierMore
  • Company Name:Absin Bioscience Inc. Gold
  • Tel:15502157206
  • Email:info@absin.cn
  •  
  • Company Name:ABCR GmbH & CO. KG Gold
  • Tel:49 721 95061 0
  • Email:info@abcr.de
  •  
  • Company Name:Shanghai TaoShu Biochemical Technology Co., Ltd. Gold
  • Tel:15002134094 021-33632979-
  • Email:service1@targetmol.com
  •  
  • Company Name:Nanjing Spring & Autumn Biological Engineering Co., Ltd. Gold
  • Tel:13815430202 025-84430028-
  • Email:sale02@cqherb.com
  •  
  • Company Name:Nanjing Yuanzhi Biotechnology Co. Ltd. Gold
  • Tel:15805159960
  • Email:1211550495@qq.com;
  •