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Forskolin

Forskolin Structure
Forskolin
  • CAS No.66575-29-9
  • Chemical Name:Forskolin
  • CBNumber:CB0167677
  • Molecular Formula:C22H34O7
  • Formula Weight:410.5
  • MOL File:66575-29-9.mol
Forskolin Property
  • Melting point: :282-232 °C
  • Boiling point: :520℃
  • alpha  :D25 -26.19° (c = 1.68 in CHCl3)
  • Density  :1.23
  • refractive index  :1.5300 (estimate)
  • Flash point: :172℃
  • storage temp.  :room temp
  • solubility  :DMSO: 5 mg/mL stable at least 6 months at room temperature
  • form  :powder
  • pka :11.00±0.70(Predicted)
  • color  :off-white
  • Water Solubility  :Soluble in ethanol, dimethylsulfoxide and chloroform. Insolule in water.
  • λmax :305nm(lit.)
  • Merck  :14,2476
  • BRN  :1692716
  • InChIKey :OHCQJHSOBUTRHG-KGGHGJDLSA-N
  • CAS DataBase Reference :66575-29-9
  • EWG's Food Scores :1
  • FDA UNII :1F7A44V6OU
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :21
  • Safety Statements  :22-36/37
  • WGK Germany  :3
  • RTECS  :QL6150000
  • F  :10-21
  • HS Code  :29329990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements H303-H315-H319-H335
  • Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Forskolin Price More Price(82)
  • Brand: Sigma-Aldrich
  • Product number: 344270
  • Product name : Forskolin
  • Purity: 
  • Packaging: 10mg
  • Price: $181
  • Updated: 2021/12/16
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  • Brand: Sigma-Aldrich
  • Product number: 1283244
  • Product name : Forskolin
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 40mg
  • Price: $619
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: F0855
  • Product name : Forskolin
  • Purity: >95.0%(HPLC)
  • Packaging: 10mg
  • Price: $137
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: F0855
  • Product name : Forskolin
  • Purity: >95.0%(HPLC)
  • Packaging: 50mg
  • Price: $473
  • Updated: 2021/12/16
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J63292
  • Product name : Forskolin, 98+%
  • Purity: 
  • Packaging: 50mg
  • Price: $583
  • Updated: 2021/12/16
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Forskolin Chemical Properties,Usage,Production

  • Chemical Properties Colorless Crystalline Solid
  • Uses Forskolin is a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP.
  • Uses glucocorticoid, antiinflammatory
  • Uses adenylate cyclase activator, antiglaucoma, hypotensive, vasodilator
  • Uses Cyclic AMP (cAMP) is an important signal carrier necessary for the proper biological response of cells to hormones, neurotransmitters, and other extracellular signals Forskolin is a naturally occurring diterpene that is produced by the Indian Coleus plant (C. forskohlii). It directly activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. Forskolin binds to adenylyl cyclase in membranes from stably transfected Sf9 cells expressing type 1 adenylyl cyclase with an IC50 value of 41 nM and demonstrates an EC50 value of 0.5 μM in an activation assay assessing formation of cAMP from ATP. Forskolin also interacts with glucose transporters and certain ion channels and has been used for examining adenylyl cyclase expression, regulation, and G protein signaling.[Cayman Chemical]
  • Uses An adenylate cyclase activator and MAP kinase inhibitor
  • Uses In purification of adenylate cyclase.
  • General Description
    Forskolin, present predominantly in the root of Coleus forskohlii plant, is a potential pharmacological compound. It is used for treating hypertension, respiratory disorders and obesity. Forskolin is a diterpenoid capable of modulating adenylate cyclase enzyme and cyclic adenosine monophosphate (cAMP) levels. Engineering forskolin biosynthetic pathway caters its commercial production for pharmacological use. Forskolin has antioxidant and anti-inflammatory property and reduces hyperglycemia by stimulating insulin release. Forskolin promotes differentiation of hepatoma HepaRG cells and activates farnesoid X receptor (FXR) and pregnane X receptor(PXR).
  • Biological Activity Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Also available as part of the PKA Tocriset™ .
  • Biochem/physiol Actions Cell permeable: yes
  • Purification Methods It is an antihypertensive, a positive ionotropic, a platelet aggregation inhibitor, and it has adenylate cyclase activating properties [Chem Abstr 89 244150 1978, de Souza et al. Med Res Rev 3 201 1983, X-ray: Tandon et al. Indian J Chem 15B 880 1977]. [Beilstein 18/5 V 55.]
Forskolin Preparation Products And Raw materials
Raw materials
Preparation Products
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66575-29-9, ForskolinRelated Search:
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  • 7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE
  • 7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-ENE-11-ONE
  • [3R-(3A,4AB,5B,6B,6AA,10A,10AB,10BA)]-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-6,10,10B-TRIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1H-NAPHTHO[2,1-B]PYRAN-1-ONE
  • 10a-beta,10b-alpha))-10-alph
  • 1-b)pyran-1-one,dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-1h-naphtho(
  • pentamethyl-6,10,10b-trihydroxy-,(3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,
  • FORSKOLIN FROM COLEUS FORSKOHLII
  • FORSKOLIN, MOLECULAR BIOLOGY REAGENT
  • FORSKOLIN 98+%
  • FORSKOLIN, 99+%
  • Forsklin
  • 1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-
  • Forskolin ForsLean Colforsin HL 362 NSC 357088 NSC 375489
  • BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE
  • FORSKOHLIN
  • FORSKOLIN
  • FORSKOLIN, COLEUS FORSKOHLII
  • COLEONOL
  • COLFORSIN
  • (3R,4AR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldod
  • Boforsin
  • Coleus forskohlii(Willd.)Briq.
  • Forskolin, 98%, from Coleus forskohlii
  • Forskolin (plant extract)
  • Forskolin ( Coleus Forskohlii extract)
  • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-b]pyran-1-one
  • ForsLean
  • HL 362
  • L 75-1362B
  • NSC 35708
  • 7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
  • Forskolin, Colforsin, Coleonol
  • FORMYL-O-BENZYL-L-SERINE
  • Coleonol, Colforsin
  • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-Naphtho[2,1-β]pyran-1-one
  • NSC 357088
  • 7SS-ACETOXY-8,13-EPOXY-1ALPHA,6SS,9ALPHA-TRIHYDROXYLABD-14-EN-11-ONE
  • Coleonol, Colforsin, 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
  • Colforsin, Boforsin
  • [3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10betaalpha)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
  • (3R,6aα)-5β-Acetoxy-3α-ethenyldodecahydro-6β,10α,10bα-trihydroxy-3,4aβ,7,7,10aβ-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
  • 7-Acetoxy-8,13-epoxy-1alpha,6,9alpha-trihydroxylabd-14-en-11-one
  • 7β-Acetoxy-8,23-epoxy-1 α
  • ForskolinColforsin
  • [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
  • NSC 375489
  • Forskolin (40 mg) (7Beta-acetoxy-8,13-epoxy-1alpha,6Beta,9alpha-trihydroxy-labd-14-en-11-one)
  • Forskolii
  • Forskolin - Coleonol
  • CS-736
  • Forskolin, Coleus forskohlii - CAS 66575-29-9 - Calbiochem
  • Forskolin &gt
  • Forskolin (Coleus forskohlii) fandachem
  • Forskolin (Fandachem)
  • (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate
  • 66575-29-9
  • G Proteins and Cyclic Nucleotides