4-Methyl-2-hexanamine hydrochloride

1,3-Dimethylpentylamine is a pseudo-adrenergic drug introduced by Lilly Company in the United States in the mid-1940s under the trade name Forthane. 1,3-dimethylpentylamine and its hydrochloride have obvious curative effects in the treatment of nasal congestion and gingival hyperplasia, and are much less stimulating to the mind than pseudoephedrine and amphetamine, and their unique pharmacological advantages cause attached great importance to the experts.

White Solid

1,3-Dimethylpentylamine is useful in composition in treating hypertrophied and hyperplastic gums which showed a significant reduction in swelling.

Methylhexanamine (hydrochloride) is a simple aliphatic amine that was once marketed as a nasal decongestant (Forthane) but is now sold as a bodybuilding supplement (Floradrene, Geranamine). It is also sold as a mild stimulant in the form of party pills and has been reported to cause cerebral hemorrhage in a case report. While little is known about its mode of action, methylhexanamine interferes in immunoassays for amphetamines, presumably because of the common ethylamine structure. This compound is intended for forensic or research purposes.[Cayman Chemical]

4-Methyl-2-hexanamine hydrochloride is a psychoactive substance and has been found to be an inhibitor of serotonin uptake, which may be related to its ability to inhibit the function of the serotonin transporter. The amount of 4-methyl-2-hexanamine hydrochloride absorbed by the body varies depending on how it is taken. When taken orally, 4-methyl-2-hexanamine hydrochloride enters through the digestive tract and reaches high levels in the blood stream. When taken intravenously, it enters the bloodstream directly and can reach higher concentrations in the blood. When inhaled, 4-methyl-2-hexanamine hydrochloride can enter into the lungs at high concentrations and then is absorbed into the bloodstream. 4-Methyl-2-hexanamine hydrochloride also degrades quickly in natural environments due to its biodegradable properties.

Methylhexanamine is a naturally substance isolated from Pelargonium graveolen. It is a component of geranium oil. Methylhexanamine is a sympathomimentic that increase levels of norepinephrine in the synaptic cleft.

At room temperature, 800 mL absolute ethanol was added into a 2 L three neck flask, stirred, and 35.38 g (1.538 mol) of metal sodium was added in batches to obtain a colorless transparent liquid. Cool slightly, add 200g (1.537 rnol) of ethyl acetoacetate, continue heating slowly, and add 232g (1.693 mol) of 2-bromobutane drop under weak reflux. Continue heating and react for 8 h at 80~84 ??. Stop heating, cool naturally to room temperature, leave it still, filter by suction, and concentrate the yellow green filtrate under reduced pressure to obtain 241.4 g of 1,3-Dimethylpentanamine Hydrochloride with light yellow viscous solid in 84.3% yield.