ChemicalBook Product Catalog Biochemical Engineering Plant extracts demethylzeylasteral

demethylzeylasteral

Product Namedemethylzeylasteral
CAS107316-88-1
MFC29H36O6
MW480.59
EINECS
MOL File107316-88-1.mol

Chemical Properties

Melting point	>221°C (dec.)
Boiling point	663.6±55.0 °C(Predicted)
Density	1.31
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	4.78±0.70(Predicted)
color	Yellow
Major Application	food and beverages
InChIKey	ZDZSFWLPCFRASW-CPISFEQASA-N
SMILES	Oc1c(c2c(cc1O)[C@@]3(CC[C@]4([C@H]5[C@@](CC[C@@]4(C3=CC2=O)C)(CC[C@@](C5)(C)C(=O)O)C)C)C)C=O

Safety Information

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

Usage And Synthesis

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Tripterygium wilfordii.

Uses

Demethylzeylasteral is a natural product as new inhibitor to block the Bcl-XL-Bid interaction. Also, it is an immunosuppressive monomer isolated from the root xylem of Tripterygium wilfordii. It exhibits inhibition towards the glucuronidation elimination reaction of SN-38.

Definition

ChEBI: A carbopolycyclic compound with formula C29H36O6, originally isolated from Tripterygium wilfordii.

Synthesis

Lei Gong Teng herbs crushed, weighed 500g, add 3L 70% ethanol ultrasonic extraction twice, extraction time for 20min, power 500W, combined extracts, concentrated to extract, add 200mlpH8 of sodium bicarbonate solution to dissolve, filtration, filtrate with . Hydrochloric acid adjusted to pH 6.5, add 300 ml of ethyl acetate extraction 2 times, combined with the extract, evaporated to get the crude demethyl zeylanol aldehyde; demethyl zeylanol aldehyde crude dissolved in methanol, microporous filtration membrane filtration, by the preparation of high-performance liquid chromatographic separation, chromatographic column: octadecyl bond and silica gel, mobile phase: acetonitrile - water (40:60), to monitor the guidance of the refractive detector monitoring The product was collected, and the collected liquid was concentrated and dried to obtain 1.42g, the content was 98.7%.

in vivo

Demethylzeylasteral (30 mg/kg, 6 times every 2 days, i.p.) inhibits glioma growth by regulating the miR-30e-5p/MYBL2 axis^[1]. Demethylzeylasteral (4 mg/kg, 5 weeks, i.p.) inhibits the invasion of triple negative breast cancer by blocking classical and non classical TGF - β signaling pathways^[2]. Demethylzeylasteral (30-120 mg/kg, 8 weeks, i.p.) improves inflammation in a unilateral ureteral obstruction rat model by inhibiting the activation of the NF - κ B pathway^[4]. Demethylzeylasteral (10, 40 mg/kg, 30 days, i.g.) can alleviate atherosclerosis in AS rabbits^[5]. Demethylzeylasteral (10, 20 mg/kg, 4 weeks, p.o.) improves CCl4 induced liver fibrosis in mice by inhibiting AGAP2 mediated FAK/AKT signaling^[6].

Animal Model:	Female nude mice modeled with glioma LN-229 cells^[1].
Dosage:	30 mg/kg, 6 times every 2 days
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced tumor volume

Animal Model:	Female BALB/c mice modeled with 4T1 cells^[2].
Dosage:	4 mg/kg, 5 weeks
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced cancer lung metastasis

Animal Model:	Rat model of unilateral ureteral obstruction^[4].
Dosage:	30-120 mg/kg, 8 weeks
Administration:	Intraperitoneal injection (i.p.)
Result:	Inhibited the increases in serum creatinine, blood urea nitrogen and Up/Ucr ratio

Animal Model:	Atherosclerotic rabbit^[5].
Dosage:	10, 40 mg/kg, 30 days
Administration:	Intragastrical (i.g.)
Result:	Reduced blood lipids triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL-C)

Animal Model:	CCl4-induced liver fibrosis model^[6].
Dosage:	10, 20 mg/kg, 4 weeks
Administration:	Oral gavage (p.o.)
Result:	Inhibited the expression of TGF-β1

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