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IBUPROFEN SODIUM SALT

Product NameIBUPROFEN SODIUM SALT
CAS31121-93-4
MFC13H17NaO2
MW228.26
EINECS250-477-6
MOL File31121-93-4.mol

Chemical Properties

Melting point	110-112 °C
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	H₂O: 100 mg/mL, may be clear to slightly hazy
form	Solid
color	White to Off-White
Water Solubility	H2O: 100mg/mL, clear to slightly hazy
Stability	Stable. Incompatible with strong oxidizing agents
Major Application	forensics and toxicology pharmaceutical (small molecule)
InChI	1S/C13H18O2.Na/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15;/h4-7,9-10H,8H2,1-3H3,(H,14,15);/q;+1/p-1
InChIKey	PTTPUWGBPLLBKW-UHFFFAOYSA-M
SMILES	[Na+].CC(C)Cc1ccc(cc1)C(C)C([O-])=O
CAS DataBase Reference	31121-93-4

Safety Information

Safety Statements	22-24/25
WGK Germany	3
RTECS	MU6641000
Storage Class	11 - Combustible Solids

MSDS

Provider	Language
SigmaAldrich	English

Usage And Synthesis

Chemical Properties

white powder

Uses

Ibuprofen ((±)-Ibuprofen) sodium is an orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen sodium inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen sodium is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen sodium can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][5][8].

Application

Ibuprofen sodium salt is a useful research chemical.

Biological Activity

Cyclooxygenase (COX) inhibitor th at has greater activity against COX-1 than against COX-2.

in vivo

Ibuprofen sodium (fed in animal feedings, 300 mg/kg, 14 days) reduces overall tumor growth and enhances anti-tumor immune characteristics without adverse autoimmune reactions in a model of postpartum breast cancer^[5].
Ibuprofen sodium (subcutaneous injection, 60 mg/kg, every second day for 15 days) reduces the risk of neuropathy in a rat model of chronic Oxaliplatininduced peripheral neuropathy^[6].
Ibuprofen sodium (oral administration, 20 mg/kg, every 12 hours, 5 doses total) decreases muscle growth (average muscle fiber cross-sectional area) without affecting regulation of supraspinatus tendon adaptions to exercise^[7].
Ibuprofen sodium (oral administration, 35 mg/kg, twice daily) attenuates the Inflammatory response to pseudomonas aeruginosa in a rat model of chronic pulmonary infection^[8].

Animal Model:	Syngeneic (D2A1) orthotopic Balb/c mouse model of PPBC (postpartum)^[5]
Dosage:	300 mg/kg, daily for 14 days
Administration:	Fed in animal feedings (added to pulverized standard chow and mixed dry, then mixed with water, made into chow pellets and dried thoroughly)
Result:	Suppresed tumor growth, reduced presence of immature monocytes and increased numbers of T cells. Enhanced Th1 associated cytokines as well as promoted tumor border accumulation of T cells.

Animal Model:	Oxaliplatininduced peripheral neuropathy^[6]
Dosage:	60 mg/kg, every second day for 15 days
Administration:	Subcutaneous injection
Result:	Lowered sensory nerve conduction velocity (SNCV).

IC 50

COX-1: 13 μM (IC₅₀); COX-2: 370 μM (IC₅₀)

References

[1] Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7. DOI:10.1021/np970343j
[2] Hassan Akrami, et al. Inhibitory effect of ibuprofen on tumor survival and angiogenesis in gastric cancer cell. Tumour Biol. 2015 May;36(5):3237-43. DOI:10.1007/s13277-014-2952-3
[3] Sharon M Rymut, et al. Ibuprofen regulation of microtubule dynamics in cystic fibrosis epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L317-27. DOI:10.1152/ajplung.00126.2016
[4] Emmanuelle Bignon, et al. Ibuprofen and ketoprofen potentiate UVA-induced cell death by a photosensitization process. Sci Rep. 2017 Aug 21;7(1):8885. DOI:10.1038/s41598-017-09406-8
[5] Nathan D Pennock, et al. Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. J Immunother Cancer. 2018 Oct 1;6(1):98. DOI:10.1186/s40425-018-0406-y
[6] Thomas Krigrd, et al. Protective effect of ibuprofen in a rat model of chronic oxaliplatin-induced peripheral neuropathy. Exp Brain Res. 2019 Oct;237(10):2645-2651. DOI:10.1007/s00221-019-05615-x
[7] Sarah Ilkhanipour Rooney, et al. Ibuprofen Differentially Affects Supraspinatus Muscle and Tendon Adaptations to Exercise in a Rat Model. Am J Sports Med. 2016 Sep;44(9):2237-45. DOI:10.1177/0363546516646377
[8] M W Konstan, et al. Ibuprofen attenuates the inflammatory response to Pseudomonas aeruginosa in a rat model of chronic pulmonary infection. Implications for antiinflammatory therapy in cystic fibrosis. Am Rev Respir Dis. 1990 Jan;141(1):186-92. DOI:10.1164/ajrccm/141.1.186

IBUPROFEN SODIUM SALT

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