Ethinyl Estradiol

Drospirenone; Ethinyl Estradiol: prevents ovulation and pregnancy. It may also be used to treat acne and premenstrual dysphoric disorder (PMDD). It belongs to a group of medications called oral contraceptives. It is a combination of the hormones estrogen and progestin.

Ethinyl estradiol (EO, a semisynthetic 17 β-oestradiol) is the highly potent estrogen. The median lethal dose (LD50) of EO has been determined to be more than 1000 μg/kg body weight, orally in female albino rats. EO caused the cytotoxicity, leading to cancer in the uterus and ovary of female albino rat. Further, EO @ 500 μg/kg, orally, weekly for 8 and 12 weeks has been reported to cause liver damage in female albino rat.