The U.S. Food and Drug Administration (FDA) labels GMS as generally safe. However, inhaling pure glycerol monostearate is toxic and it may irritate the skin, eyes and respiratory and digestive tracts.
Although it is generally safe, overusing glycerol monostearate may cause side effects. Because it draws fluid from the brain and eyes into the muscles and other parts of the body, excessive amounts of GMS may cause headaches or blurred vision. Some other side effects of glycerol may include: Excessive thirst, Diarrhea, Vomiting, Dizziness Allergic Reactions, Bloating, Stomach pain, Inflammation in the GI tract, Increases Cholesterol Levels (when consumed in excessive), Muscle Cramps (when consumed in excess).