チアンフェニコール

￥5700 - ￥87500

化学名チアンフェニコール

英語名Thiamphenicol

CAS番号15318-45-3

分子式C12H15Cl2NO5S

分子量356.22

EINECS239-355-3

MDL NumberMFCD00467983

别名

メチルスルホニルクロラムフェニコール

チオサミノール

チアムフェニコール

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価格 21 物価

生産者	包装単位	価格	製品説明
富士フイルム和光純薬株式会社(wako) W01FLC510285	25g	￥87500	チアムフェニコール Thiamphenicol
富士フイルム和光純薬株式会社(wako) W01COBQD-7868	10g	￥50400	Thiamphenicol
富士フイルム和光純薬株式会社(wako) W01COBQD-7868	25g	￥35000	チアムフェニコール Thiamphenicol
富士フイルム和光純薬株式会社(wako) W01FLC510285	5g	￥27500	チアムフェニコール Thiamphenicol
富士フイルム和光純薬株式会社(wako) W01TRCT344160	1g	￥24000	チアムフェニコール Thiamphenicol
富士フイルム和光純薬株式会社(wako) W01TRCT344160	100mg	￥20400	チアムフェニコール Thiamphenicol
富士フイルム和光純薬株式会社(wako) W01COBQD-7868	5g	￥12500	チアムフェニコール Thiamphenicol
富士フイルム和光純薬株式会社(wako) W01FLC510285	1g	￥12500	チアムフェニコール Thiamphenicol
富士フイルム和光純薬株式会社(wako) W01COBQD-7868	1g	￥10000	Thiamphenicol
富士フイルム和光純薬株式会社(wako) W01W0120-1392	200mg	￥8800	チアンフェニコール標準品 Thiamphenicol Standard

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プロパティ

融点	163-166 °C
比旋光度	D25 +12.9° (ethanol)
比重(密度)	1.3281 (rough estimate)
屈折率	1.6000 (estimate)
貯蔵温度	Sealed in dry,Room Temperature
溶解性	ethanol: 50 mg/mL, clear, colorless
沸点	695.9±55.0 °C(Predicted)
酸解離定数(Pka)	11.05±0.46(Predicted)
外見	powder
色	white to off-white
水溶解度	Soluble in acetonitrile or DMF. Slightly soluble in water
Merck	14,9301
BRN	2819542
InChIKey	OTVAEFIXJLOWRX-NXEZZACHSA-N
CAS データベース	15318-45-3
EPAの化学物質情報	Thiamphenicol (15318-45-3)

安全情報

説明

Thiamphenicol is a broad-spectrum antibiotic chloramphenicol, which is more effective to the gram-negative bacteria than the gram-positive bacteria. At room temperature, it is a white to off-white crystalline powder or crystal, which can be quickly and completely absorped by oral adminstration, as well as it is excreted mainly in the prototype from the urine for metabolism. It is clinically applied for the treatment of respiratory, urinary tract, liver and gallbladder, typhoid and other intestinal surgery, gynecology and ENT infections. Especially in the mild infections it is more effective. It has the similar chemical structure with the chloramphenicol. Its methyl sulfone substituted the nitro of chloramphenicol, which reduced its toxicity, and in vivo its antibacterial activity is 2.5-5 times stronger than chloramphenicol. For gram-positive bacteria, such as streptococcus pneumoniae and hemolytic streptococcus, it has very strong antibacterial effect, while for gram-negative bacteria, such as Neisseria gonorrhoeae, meningococcus, lung Bacteroides, E. coli, Vibrio cholerae, Shigella and influenza bacillus, it also has strong antibacterial effect. For anaerobic bacteria, Rickettsia and amoeba, it has antibacterial effect in some extent. It has the same antimicrobial mechanism with chloramphenicol, which mainly inhibits the synthesis of bacterial protein. This drug is absorped quickly by oral administration, which reaches peak blood concentration within two hours. Its half-life is 5 hours, that is more longer than chloramphenicol. The bacteria have complete cross resistance to it and chloramphenicol, while the bacteria have some cross-resistance phenomenon to it and tetracycline.
Thiamphenicol also has strong immunosuppressive effects, which is an excellent immunosuppressant. Its mechanism of action have significantly different with other immunosuppressive agents. The immunosuppressive effect is several times higher than the chloramphenicol. It can be as the effective extender for transplantation reaction and surgically allogeneic transplantation.

チアンフェニコール

プロパティ

安全情報

説明

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