Trelagliptin

$29 - $1208.7

Product nameTrelagliptin
Cas No865759-25-7
MFC18H20FN5O2
MW357.38
EINECS1592732-453-0
MDL NumberMFCD22572746

Synonyms

Trelagliptin(syr472);Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H) -pyrimidinyl]methyl]-4-fluoro-;Trelagliptin (R)-2-[[6-(3-Aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]methyl]-4-fluorobenzonitrile;(S)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile;Trelagliptin Isomer Impurity;Trelagliptin, >=98%;Trelagliptin free base;Trelagliptin

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Price

61 prices

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aablocks Crysdot ChemScene Ark Pharm ApexBio Technology Cayman Chemical Arctom AK Scientific DC Chemicals TRC Biorbyt Ltd Usbiological
Package less more

2.5mg 25mg 250mg 500mg 10mm*1mlindmso(solution) 1g 1000mg 1mg 10mm(in1mldmso) 5mg 10mg 50mg 100mg 10mm*1mlindmso(solid+solvent)

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Brand	Packaging	Price	Product name
aablocks AA00IE1Y	5mg	$29	Trelagliptin
aablocks AA00IE1Y	10mg	$36	Trelagliptin
aablocks AA00IE1Y	50mg	$44	Trelagliptin
aablocks AA00IE1Y	100mg	$53	Trelagliptin
aablocks AA00IE1Y	250mg	$100	Trelagliptin
AK Scientific 2763AH	10mg	$166	Trelagliptin
ApexBio Technology A3888	5mg	$80	Trelagliptin
ApexBio Technology A3888	10mg	$88	Trelagliptin
ApexBio Technology A3888	5mg	$55	Trelagliptin
ApexBio Technology A3888	10mM(in1mLDMSO)	$61	Trelagliptin

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Properties

Boiling point	519.0±60.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	≥11.6 mg/mL in DMSO; ≥3.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥93.8 mg/mL in H2O
form	solid
pka	9.88±0.20(Predicted)
color	White to off-white
InChI	InChI=1S/C18H20FN5O2/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3/t15-/m1/s1
InChIKey	IWYJYHUNXVAVAA-OAHLLOKOSA-N
SMILES	C(#N)C1=CC=C(F)C=C1CN1C(=O)N(C)C(=O)C=C1N1CCC[C@@H](N)C1

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Dipeptidyl peptidase 4 (DPP-4) is an intrinsic membrane glycoprotein that acts as an exopeptidase, cleaving oligopeptides after the second amino acid from the N-terminal end. One of its substrates is glucagon-like peptide 1, an incretin that stimulates insulin biosynthesis and secretion while inhibiting glucagon release in a glucose-dependent manner. Trelagliptin is a pyrimidinedione-based, long-acting inhibitor of DPP-4 (IC50 = 4 nM). It demonstrates >10,000-fold selectivity over other peptidases. Trelagliptin has been used to improve glucose tolerance and postprandial plasma insulin levels in Zucker fa/fa rats. In 2014 this compound underwent phase III clinical trials.

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Suppliers and manufacturers

Henan Bao Enluo International TradeCo.，LTD

$150.00

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Zibo Hangyu Biotechnology Development Co., Ltd

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career henan chemical co

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HubeiwidelychemicaltechnologyCo.,Ltd

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