Slv320

$11 - $2200

Product nameSlv320
Cas No251945-92-3
MFC18H20N4O
MW308.38

Synonyms

Cyclohexanol, 4-((2-phenyl-1H-pyrrolo(2,3-D)pyrimidin-4-yl)amino)-, trans-;Slv320;trans-4-[(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol;(1R,4R)-4-(2-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexanol;SC-204288;4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexanol;SLV320; SLV-320; SLV 320; DERENOFYLLINE;Cyclohexanol, 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-, trans-

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Price

39 prices

Brand less more

Sigma-Aldrich Cayman Chemical CSNpharm ACHEMBLOCK aablocks Tocris TRC Usbiological ApexBio Technology AK Scientific ChemScene American Custom Chemicals Corporation Ambeed DC Chemicals
Package less more

50 1mg 10 5mg 10mg 25mg 50mg 100mg 250mg 1g

Clear All Done

Brand	Packaging	Price	Product name
aablocks AA002QRH	1mg	$11	Derenofylline
aablocks AA002QRH	5mg	$13	Derenofylline
aablocks AA002QRH	10mg	$16	Derenofylline
aablocks AA002QRH	50mg	$75	Derenofylline
aablocks AA002QRH	100mg	$87	Derenofylline
aablocks AA002QRH	250mg	$174	Derenofylline
ACHEMBLOCK T101922	1G	$660	Derenofylline
ACHEMBLOCK T101922	100MG	$110	Derenofylline
AK Scientific 4484CR	50mg	$509	Derenofylline
Ambeed A887654	250mg	$255	Slv320

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Properties

Boiling point	532.3±60.0 °C(Predicted)
Density	1.37±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Soluble to 100 mM in DMSO and to 50 mM in ethanol
form	Powder
pka	15.15±0.40(Predicted)
color	White to off-white
InChI	1S/C18H20N4O/c23-14-8-6-13(7-9-14)20-18-15-10-11-19-17(15)21-16(22-18)12-4-2-1-3-5-12/h1-5,10-11,13-14,23H,6-9H2,(H2,19,20,21,22)
InChIKey	RBZNJGHIKXAKQE-UHFFFAOYSA-N
SMILES	O[C@H]1CC[C@@H](CC1)NC2=NC(C3=CC=CC=C3)=NC4=C2C=CN4

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Derenofylline is an adenosine A₁ receptor antagonist (K_i = 1 nM). It is selective for adenosine A₁ over A_2A, A_2B, and A₃ receptors (K_is = 398, 3,981, and 200 nM, respectively). It decreases adenosine A₁ receptor-mediated adenosine-induced bradycardia in rats (ED₅₀ = 0.49 mg/kg) but reduces A₂ receptor-mediated adenosine-induced hypotension by only 44.6% when administered at an intravenous dose of 5 mg/kg. It prevents increases in heart levels of collagen I and III in nephrectomized rats when administered at a dose of 10 mg/kg per day. Derenofylline also reduces relative plaque counts in a Zika virus plaque-forming assay in A549 cells (IC₅₀ = 58.6 nM) in an adenosine A₁ receptor-independent manner without inducing cytotoxicity when used at concentrations less than 10 μM.

Related product price

Slv320 $11-2200 (R)-(+)-4'-HYDROXYPHENYL-CARVEDILOL $69-1963.5 CARVEDILOL-D5 $169-1455

Suppliers and manufacturers

TargetMol Chemicals Inc.
3B Pharmachem (Wuhan) International Co.,Ltd.
EMMX Biotechnology LLC
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
Tianjin Kailiqi Biotechnology Co., Ltd.
Shanghai Chaolan Chemical Technology Center
Beijing Minruida Technology Co., Ltd.
Jiangsu aikang biomedical research and development co., LTD
Career Henan Chemica Co

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