Roscovitine

$22 - $2245.7

Product nameRoscovitine
Cas No186692-46-6
MFC19H26N6O
MW354.45
MDL NumberMFCD02266401

Synonyms

2-(R)-[[9-(1-Methylethyl)-6-[(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, 6-(Benzylamino)-2(R)-[[1-(hydroxymethyl)propyl]amino]-9-isopropylpurine;(2R)-2-[[6-(benzylamino)-9-propan-2-yl-purin-2-yl]amino]butan-1-ol;2-(R)-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE;2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE;6-BENZYLAMINO-2-(R)-[(1-ETHYL)-2-HYDROXYETHYLAMINO]-9-ISOPROPYLPURINE;ROSCOVITINE;(R)-ROSCOVITINE;(R)-2-(1-ETHYL-2-HYDROXYETHYLAMINO)-6-BENZYLAMINO-9-ISOPROPYLPURINE

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Price

54 prices

Brand less more

Sigma-Aldrich Cayman Chemical CSNpharm Arctom Tocris Usbiological Biorbyt Ltd ApexBio Technology AK Scientific Adipogen Life Sciences ChemScene American Custom Chemicals Corporation Biosynth Carbosynth Ambeed Labseeker DC Chemicals
Package less more

500μg 50 1mg 10 2.5mg 10mm(in1mldmso) 2mg 5mg 10mg 20mg 25mg 50mg 100mg 200mg 250mg 500mg 1g

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Brand	Packaging	Price	Product name
Adipogen Life Sciences AG-CR1-0006-M005	5mg	$90	(R)-Roscovitine
Adipogen Life Sciences AG-CR1-0006-M050	50mg	$270	(R)-Roscovitine
AK Scientific X7381	50mg	$224	Roscovitine
Ambeed A300507	100mg	$207	Roscovitine
Ambeed A300507	50mg	$122	Roscovitine
Ambeed A300507	5mg	$29	Roscovitine
Ambeed A300507	10mg	$49	Roscovitine
Ambeed A300507	250mg	$424	Roscovitine
Ambeed A300507	1g	$1027	Roscovitine
American Custom Chemicals Corporation KIN0000355	25MG	$1871.1	Roscovitine

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Properties

Melting point	106～107℃
Boiling point	577.5±60.0 °C(Predicted)
Density	1.3
storage temp.	-20°C
solubility	Soluble in DMSO (up to 10 mg/ml, with warming) or in Ethanol (up to 10 mg/ml).
form	White to off-white solid
pka	14.56±0.10(Predicted)
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey	BTIHMVBBUGXLCJ-OAHLLOKOSA-N
CAS DataBase Reference	186692-46-6(CAS DataBase Reference)

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P271：Use only outdoors or in a well-ventilated area.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

P501：Dispose of contents/container to..…

Description

Roscovitine is a potent and selective inhibitor of cyclin-dependent kinases which suppresses the proliferation of mammalian cell lines. Selective for Cdk1/cyclin B kinase (IC₅₀=450nM), Cdk2 (IC₅₀=700nM) and Cdk5/p35 (IC₅₀=160nM). Roscovitine is more potent than olomoucine (sc-201526). It inhibits M phase promoting factor kinase activity and affects calcium channel gating. Roscovitine reversibly inhibits the transition from prophase to metaphase at micromolar concentrations in starfish oocytes and sea urchin embryos. It also inhibits in vitro M-phase-promoting factor activity and in vitro DNA synthesis in Xenopus egg extracts. A recent study shows that roscovitine inhibits Cdk5 kinase activity, cell proliferation, multicellular development, and Cdk5 nuclear translocation in Dictyostelium discoideum, without affecting the expression of Cdk5 protein during axenic growth. Roscovitine is an inhibitor of Cdk7, cyclin B, cyclin E, cyclin A, cyclin H, cdc2 and p53.

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Suppliers and manufacturers

career henan chemical co

$1.00/1KG

ROSCOVITINE

CAS:186692-46-6
TargetMol Chemicals Inc.

$40.00/5mg

Seliciclib

CAS:186692-46-6
Hangzhou FandaChem Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Biochempartner
Hubei xin bonus chemical co. LTD
Alchem Pharmtech,Inc.
CONIER CHEM AND PHARMA LIMITED
Shanghai Gubang New Materail Technology Co. LTD
HANGZHOU CLAP TECHNOLOGY CO.,LTD

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