Everolimus

$8 - $3165

Product nameEverolimus
Cas No159351-69-6
MFC53H83NO14
MW958.22
EINECS621-003-9
MDL NumberMFCD00929329

Synonyms

Rapamycin, 42-O-(2-hydroxyethyl)-;Everolimus;Certican;CERTICAN(R);EveroliMus(RAD-001);(1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-Methoxycyclohexyl]propan-2-yl]-19,30-diMethoxy-15,17,21,23,29,35-hexaMethyl-11,36-dioxa-4-azatricyclo[30.3.1.0^{4,9}]hexatriaconta-16,2;EveroliMus API;23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv

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Price

153 prices

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Ambeed aablocks ApexBio Technology Adipogen Life Sciences ACHEMBLOCK AvaChem Arctom Cayman Chemical ChemScene Biosynth TRC AK Scientific IsoSciences CSNpharm Sigma-Aldrich DC Chemicals Biorbyt Ltd Tocris Usbiological Crysdot Labseeker Medical Isotopes, Inc. American Custom Chemicals Corporation Matrix Scientific
Package less more

20mg 10mm(1mlindmso) 10 10mm*1mlindmso y0002048 1mg 1unit 5mg 10mg y0002061 y0002063 25mg 50mg 0.05g 70mg 0.1g 100mg 200mg 0.25g 250.00mg 250mg 300mg 0.5g 500mg 1.00g 1ml 10mm(in1mldmso) 10g evaluationsample 1g

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Brand	Packaging	Price	Product name
aablocks AA001QJO	5mg	$16	40-O-(2-Hydroxyethyl)rapamycin
aablocks AA001QJO	25mg	$40	40-O-(2-Hydroxyethyl)rapamycin
aablocks AA001QJO	50mg	$54	40-O-(2-Hydroxyethyl)rapamycin
aablocks AA001QJO	100mg	$76	40-O-(2-Hydroxyethyl)rapamycin
aablocks AA001QJO	250mg	$123	40-O-(2-Hydroxyethyl)rapamycin
aablocks AA001QJO	1g	$324	40-O-(2-Hydroxyethyl)rapamycin
aablocks AA001QJO	10g	$3165	40-O-(2-Hydroxyethyl)rapamycin
ACHEMBLOCK 10532	1G	$450	Everolimus
ACHEMBLOCK 10532	100MG	$90	Everolimus
ACHEMBLOCK 10532	25MG	$35	Everolimus

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Properties

Melting point	NA
Boiling point	998.7±75.0 °C(Predicted)
Density	1.18±0.1 g/cm3(Predicted)
Flash point	2℃
storage temp.	-20°C
solubility	Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).
form	solid
pka	10.40±0.70(Predicted)
color	White
Water Solubility	Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.
Stability	Hygroscopic
Major Application	pharmaceutical
InChIKey	HKVAMNSJSFKALM-GKUWKFKPSA-N

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H351：Suspected of causing cancer

H373：May cause damage to organs through prolonged or repeated exposure

H410：Very toxic to aquatic life with long lasting effects

Precautionary statements

P202：Do not handle until all safety precautions have been read and understood.

P260：Do not breathe dust/fume/gas/mist/vapours/spray.

P273：Avoid release to the environment.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313：IF exposed or concerned: Get medical advice/attention.

P391：Collect spillage. Hazardous to the aquatic environment

Description

Everolimus is a Kinase Inhibitor. It’s brand name is Afinitor. Everolimus is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties.The mechanism of action of everolimus is as a Protein Kinase Inhibitor, and Cytochrome P450 3A4 Inhibitor, and P-Glycoprotein Inhibitor, and Cytochrome P450 2D6 Inhibitor.
In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.
Everolimus is a biological therapy treatment for
Advanced breast cancer if you have been through the menopause (post menopausal). You take it with the hormone therapy drug exemestane
Advanced kidney cancer that has come back either during or after treatment.
Neuroendocrine tumours of the pancreas that can't be removed with surgery or have spread (metastatic disease).
Researchers are also looking at everolimus as a treatment for head and neck cancer and cancer of the food pipe (oesophageal cancer).

Related product price

Rapamycin $9-6160 Etofenamate $49-1840 Etoposide $9-17300

Suppliers and manufacturers

Henan Bao Enluo International TradeCo.，LTD

$100.00

Everolimus

CAS:159351-69-6
Shaanxi Haibo Biotechnology Co., Ltd

Everolimus

CAS:159351-69-6
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Everolimus

CAS:59351-69-6
Xi an Biohorlden Industry Trade Co Ltd

Everolimus

CAS:159351-69-6
Wuhan JiyunZen Tech Co., Ltd.

Everolimus

CAS:159351-69-6
AFINE CHEMICALS LIMITED
Seasons Biotechnology Co., Ltd.
Capot Chemical Co.,Ltd.
Beijing Cooperate Pharmaceutical Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.

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