Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties. It is a small molecule inhibitor of hypoxia-inducible factor (HIF) signaling, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations. Chetomin effectively attenuates the HIF pathway both in cells and in vivo, in mice. It inhibits HIF-dependant signaling, cell growth, and tumor growth in cancer cells and xenografts.
