Basic information Safety Related Supplier

CHAETOMIN

Basic information Safety Related Supplier
CHAETOMIN Basic information
CHAETOMIN Chemical Properties
  • Melting point:218-220℃ (chloroform )
  • Density 1.78±0.1 g/cm3(Predicted)
  • storage temp. -20°C
  • solubility DMSO: soluble
  • form Off-white to fawn solid.
  • pka12.69±0.10(Predicted)
Safety Information
  • Hazard Codes T
  • Risk Statements 25
  • Safety Statements 45
  • RIDADR UN 2811 6.1 / PGIII
  • WGK Germany 3
CHAETOMIN Usage And Synthesis
  • DefinitionChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.
  • Biochem/physiol ActionsChetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.
CHAETOMIN(1403-36-7)Related Product Information
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  • Company Name:J & K SCIENTIFIC LTD.
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  • Company Name:Sigma-Aldrich
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