PricePropertiesSafety InformationDescription

BOLDINE DIMETHYL ETHER

  • $25 - $288
  • Product name:BOLDINE DIMETHYL ETHER
  • CAS:475-81-0
  • MF: C21H25NO4
  • MW:355.43
  • EINECS:207-501-5
  • MDL Number:MFCD00075953
  • Synonyms:bromcholitin ;d-glaucine ;glauvent ;(+)-GLAUCINE;GLAUCINE;BOLDINE DIMETHYL ETHER;1,2,9,10-TETRAMETHOXYAPORPHINE;(S)-1,2,9,10-TETRAMETHOXY-6-METHYL-5,6,6A,7-TETRAHYDRO-4H-DIBENZO[DE,G]QUINOLINE
Price
  • Brand:Cayman Chemical
  • Product number:17338
  • Product nameGlaucine
  • Purity:≥95%
  • Packaging:1mg
  • Price:$25
  • Updated:2020/6/24 11:48:41
  • Buy:Buy
  • Brand:Cayman Chemical
  • Product number:17338
  • Product nameGlaucine
  • Purity:≥95%
  • Packaging:5mg
  • Price:$94
  • Updated:2020/6/24 11:48:41
  • Buy:Buy
  • Brand:Cayman Chemical
  • Product number:17338
  • Product nameGlaucine
  • Purity:≥95%
  • Packaging:10mg
  • Price:$138
  • Updated:2020/6/24 11:48:41
  • Buy:Buy
  • Brand:Cayman Chemical
  • Product number:17338
  • Product nameGlaucine
  • Purity:≥95%
  • Packaging:50mg
  • Price:$288
  • Updated:2020/6/24 11:48:41
  • Buy:Buy
  • 1
Properties
  • Melting point:246-247℃
  • alpha D20 +115° (c = 3 in alc)
  • Boiling point:488.45°C (rough estimate)
  • Density 1.166±0.06 g/cm3 (20 ºC 760 Torr)
  • refractive index 1.5614 (estimate)
  • pka6.35±0.20(Predicted)
Safety Information
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Description

Glaucine is an alkaloid originally isolated from G. flavum that demonstrates antitussive properties. It is structurally related to papaverine , a non-selective phosphodiesterase (PDE) inhibitor. Glaucine selectively inhibits PDE4 (Kis = 3.4 μM in human bronchus and polymorphonuclear leukocytes). It has been shown to have bronchodilation and anti-inflammatory effects, inhibiting the spontaneous and histamine-induced tone in human isolated bronchus and augmenting cyclic AMP accumulation. Glaucine also binds to the benzothiazepine site on L-type Ca2+-channels in smooth muscle, blocking calcium ion signaling. This compound has been detected as a recreational drug capable of eliciting dissociative effects.


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