1-(5-Bromo-4-methylthiophen-2-yl)ethanone is an important intermediate in the synthesis of retinoic acid, isotretinoin and acitretin; it can also be used in organic synthesis and synthesis of chiral drugs. As an intermediate, it can be used in the production of agrochemicals imidacloprid and acetamiprid, and pharmaceuticals. At the same time, it is also the intermediate material of pioglitazone mainly used for the treatment of type II diabetes.