Inosine-5'-monophosphate (IMP) is a substrate of IMP dehydrogenase (IMPDH), a NAD+-dependent enzyme that generates xanthosine monophosphate. This is a rate-limiting step in the generation of guanosine monophosphate, which is important for DNA, RNA, and glycoprotein synthesis. Inhibitors of IMPDH, including ribavirin and mycophenolate mofetil , have potential applications as antiviral and anti-cancer drugs. 5-Ribonucleosides, including IMP, are also involved in potentiating the umami taste sensation.
