L-글루타민

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

L-글루타민 MSDS

• 2-Aminoglutaramic acid

L-글루타민 화학적 특성, 용도, 생산

• 순도시험

    (1) 비선광도 : 이 품목을 미리 건조한 다음 4g을 정밀히 달아 물에 녹여 100mL로 하여 이 액의 선광도를 측정할 때, ＝ +6.3～+7.3°이어야 한다.

    (2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 5.0ppm 이하이어야 한다.

    (3) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

    (4) 염화물 : 이 품목 0.07g을 취하여 염화물시험법에 따라 시험할 때, 그 양은 0.01N 염산 0.2mL에 대응하는 양 이하이어야 한다(0.1% 이하).

• 확인시험

    이 품목의 수용액(1→1,000) 5mL에 닌히드린시액 1mL를 가하여 수욕조에서 3분간 가열하면 자색을 나타낸다.

• 정량법

    이 품목을 건조한 다음 약 0.5g을 정밀히 달아 「L-글루탐산나트륨」의 정량법에 따라 정량한다.

  0.1N 과염소산용액 1mL＝14.62mg C₅H₁₀N₂O₃

• 강열잔류물

    이 품목의 강열잔류물은 0.1% 이하이어야 한다.

• 개요

  Glutamine (abbreviated as Gln or Q) is one of the 20 amino acids encoded by the standard genetic code. It is not recognized as an essential amino acid, but may become conditionally essential in certain situations, including intensive athletic training or certain gastrointestinal disorders.Its side-chain is an amide formed by replacing the side-chain hydroxyl of glutamic acid with an amine functional group, making it the amide of glutamic acid. Its codons are CAA and CAG. In human blood, glutamine is the most abundant free amino acid, with a concentration of about 500–900 μmol / l .

• 화학적 성질

  L-glutamine is odorless, but has a slightly sweet taste L-glutamine performs a major role in DNA synthesis and sup- ports the immune system by means of glutathione synthesis.

• 출처

  Occurrences in nature
  Glutamine is the most abundant naturally occurring, nonessential amino acid in the human body, and one of the few amino acids that can directly cross the blood-brain barrier.In the body, it is found circulating in the blood, as well as stored in the skeletal muscles. It becomes conditionally essential (requiring intake from food or supplements) in states of illness or injury.Dietary sources
  Dietary sources of L-glutamine include beef, chicken, fish, eggs, milk, dairy products, wheat, cabbage, beets, beans, spinach, and parsley. Small amounts of free L-glutamine are also found in vegetable juices.
  Aiding gastrointestinal functionGlutamine-enriched diets have been linked with maintenance of gut barrier function and cell differentiation, suggesting glutamine may help to protect the lining of the gastrointestinal tract or mucosa. People who have inflammatory bowel disease (ulcerative colitis and Crohn' s disease) may not have enough glutamine, but two clinical trials found taking glutamine supplements did not improve symptoms of Crohn' s disease.

• 용도

  L-Glutamine is an essential amino acid that is a crucial component of culture media that serves as a major energy source for cells in culture. L-Glutamine is very stable as a dry powder and as a frozen solution. In liquid media or stock solutions, however, L-glutamine degrades relatively rapidly. Optimal cell performance usually requires supplementation of the media with L-glutamine prior to use.

• 정의

  ChEBI: An optically active form of glutamine having L-configuration.

• 제조 방법

  By isolation from sugar beet juice.

• Biological Functions

  Glutamine plays a role in a variety of biochemical functions, including :
  Protein synthesis, as any other of the 20 proteinogenic amino acids
  Regulation of acid-base balance in the kidney by producing ammonium
  Cellular energy, as a source, next to glucose
  Nitrogen donation for many anabolic processes, including the synthesis of purines
  Carbon donation , as a source , refilling the citric acid cycle
  Nontoxic transporter of ammonia in the blood circulation.

• 일반 설명

  Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. L-glutamine is the most abundant amino acid in the body. It is essential for the synthesis of L-asparagine. It also helps in muscle growth through protein synthesis and increased growth hormone levels.

• Safety Profile

  Mddly toxic by ingestion. Human systemic effects: euphoria. When heated to decomposition it emits toxic fumes of NOx.

• Purification Methods

  Likely impurities are glutamic acid, ammonium pyroglutamate, tyrosine, asparagine, isoglutamine, arginine. Crystallise it from water or aqueous EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1929-1925 1961, Beilstein 4 IV 3038.]

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