라니티딘

한글명:라니티딘

카스 번호66357-35-5

상품명:Ranitidine

CBNumberCB5480252

분자식C13H22N4O3S

포뮬러 무게314.4

MOL 파일66357-35-5.mol

동의어(한글)

라니티딘

화학적 성질

녹는점	69-70°C
끓는 점	437.1±45.0 °C(Predicted)
밀도	1.184±0.06 g/cm3(Predicted)
저장 조건	Desiccate at +4°C
용해도	H₂O: 1.8 mg/mL
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	pKa 2.19±0.04 (Uncertain)
색상	갈색을 띤 노란색
수용성	24.7mg/mL
안정성	흡습성
CAS 데이터베이스	66357-35-5(CAS DataBase Reference)
NIST	Ranitidine(66357-35-5)
EPA	1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro- (66357-35-5)

위험 및 안전 성명

안전지침서	22-24/25
WGK 독일	2
RTECS 번호	KM6557000
유해 물질 데이터	66357-35-5(Hazardous Substances Data)
독성	LD50 oral in rat: > 5gm/kg

그림문자(GHS)

라니티딘 MSDS

라니티딘 화학적 특성, 용도, 생산

개요
Ranitidine, a H2-receptor agonist, caused contact dermatitis within the pharmaceutical industry.
용도
Ranitidine (cas# 66357-35-5) was used as a standard for testing the therapeutic effect of brown propolis extract against aspirin and ethanol- induced gastric ulcers.
Indications
Ranitidine (Zantac) is another H2 receptor antagonist that does not have the same antiandrogen side effects as cimetidine. Note that both cimetidine and ranitidine inhibit the cytochrome P-450 microsomal enzyme system.
일반 설명
Ranitidine, N-[2-[[[5-(dimethylamino)methyl]-2-furanyl]methyl]thiol] ethyl]-N'-methyl-2-nitro-l,1-ethenediamine (Zantac), is a white solid, which inits hydrochloride salt form is highly soluble in water. It is anaminoalkyl furan derivative with pKa values of 2.7 (sidechain) and 8.2 (dimethylamino). Ranitidine is more potentthan cimetidine, but less potent than famotidine. Likeother H2-antagonists, it does not appear to bind to otherreceptors.
Bioavailability of an oral dose of ranitidine is about 50%and is not significantly affected by the presence of food.Some antacids may reduce ranitidine absorption and shouldnot be taken within 1 hour of administration of this drug. Theplasma half-life of the drug is 2 to 3 hours, and it is excretedalong with its metabolites in the urine. Three metabolites, ranitidineN-oxide, ranitidine S-oxide, and desmethyl ranitidine,have been identified. Ranitidine is only a weak inhibitor ofthe hepatic cytochrome isozymes, and recommended doses ofthe drug do not appear to inhibit the metabolism of otherdrugs. However, there have been isolated reports of drug interactions(warfarin, triazolam) that suggest that ranitidinemay affect the bioavailability of certain drugs by someunidentified mechanism, perhaps by pH-dependent effect onabsorption or a change in volume of distribution.
In addition to being available in various dosage forms asthe hydrochloride salt, ranitidine is also available as a bismuthcitrate salt for use with the macrolide antibiotic clarithromycinin treating patients with an active duodenalulcer associated with H. pylori infection. Eradication of H.pylori reduces the risk of duodenal ulcer recurrence.
생물학적 활성
Potent, selective and competitive histamine H 2 receptor antagonist (pA 2 = 6.95-7.2). In vivo, inhibits gastric acid secretion induced by histamine, pentagastrin, bethanecol and food. Also inhibits aspirin-induced gastric lesions.
색상 색인 번호
Ranitidine, an H2-receptor antagonist, can cause contact dermatitis within the pharmaceutical industry and in health care workers, or may induce systemic drug reactions in patients.

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