2-옥틸-1-도데칸올

2-옥틸-1-도데칸올 화학적 특성, 용도, 생산

• 화학적 성질

  2-Octyl-1-dodecanol is clear, colourless or yellowish, oily liquid.

• 용도

  2-Octyl-1-dodecanol have been used as a emulsion stabilizer for polymer matrix patches.

• 생산 방법

  2-Octyl-1-dodecanol is produced by the condensation of two molecules of decyl alcohol. It also occurs naturally in small quantities in plants.

• 일반 설명

  Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

• Pharmaceutical Applications

  Octyldodecanol is widely used in cosmetics and pharmaceutical applications as an emulsifying and opacifying agent. It is primarily used in topical applications because of its lubricating and emollient properties.
  Octyldodecanol has been used in the preparation of oil/water microemulsions investigated as the vehicle for the dermal administration of drugs having no or low skin penetration.Octyldodecanol has also been evaluated as a solvent for naproxen when applied topically.Studies of estimated permeability coefficient suggest that octyldodecanol could be a potential dermal permeation enhancer.

• Safety Profile

  An eye and severe skin irritant.When heated to decomposition it emits acrid smoke andirritating vapors.

• Safety

  Octyldodecanol is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as nontoxic and nonirritant at the levels employed as an excipient.
  In acute oral toxicity studies in rats fed 5 g/kg of undiluted octyldodecanol, no deaths were observed.In an acute dermal toxicity study, intact and abraded skin sites of guinea pigs were treated with 3 g/kg of undiluted octyldodecanol under occlusive patches; no deaths occurred and no gross skin lesions were observed.Octyldodecanol caused either no ocular irritation or minimal, transient irritation in the eyes of rabbits.However, some sources describe undiluted octyldodecanol as an eye and severe skin irritant.

• 저장

  The bulk material should be stored in a well-closed container in a cool, dry place, protected from light. In the original unopened container, octyldodecanol can be stored for 2 years protected from moisture at below 30°C.

• 비 호환성

  2-Octyl-1-dodecanol is generally compatible with most materials encountered in cosmetic and pharmaceutical formulations.

• Regulatory Status

  Included in the FDA Inactive Ingredients Database (topical, transdermal, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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