트리톤액스100

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H318：눈에 심한 손상을 일으킴

  H410：장기적 영향에 의해 수생생물에 매우 유독함

• 예방조치문구

  P264：취급 후에는 손을 철저히 씻으시오.

  P264：취급 후에는 손을 철저히 씻으시오.

  P273：환경으로 배출하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P301+P312：삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

  P302+P352：피부에 묻으면 다량의 물로 씻으시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

트리톤액스100 화학적 특성, 용도, 생산

• 개요

  Triton X-100 is a nonionic surfactant that has a hydrophilic polyethylene oxide chain (on average it has 9.5 ethylene oxide units) and an aromatic hydrocarbon lipophilic or hydrophobic group. The hydrocarbon group is a 4-(1,1,3,3-tetramethylbutyl)-phenyl group. Triton X-100 is closely related to IGEPAL CA-630 or former Nonidet P-40, which might differ from it mainly in having slightly shorter ethylene oxide chains. Thus Triton X-100 is slightly more hydrophilic than Igepal CA-630; these two detergents may not be considered to be functionally interchangeable for most applications.
  Triton X-100 is a common non-ionic surfactant and emulsifier which is often used in biochemical applications to solubilize proteins. It is considered a comparatively mild detergent, non-denaturing, and is reported in numerous references as a routinely added reagent. It is utilized for lysing cells to extract protein and cellular organelles. It can also permeabilize the living cell membrane for transfection.

• 화학적 성질

  Triton X-100 is a very stable material, assumed to be stable for years if stored sealed. It is a clear to slightly hazy, colorless to light yellow liquid (color by APHA = 100).
  1. Specific gravity: 1.065 at 25°C (Approx. 1.07 g/mL).
  2. Approximate molecular weight = 625, giving effective molarity = 1.7 M for the neat liquid.
  3. UV absorption: lambda max = 275 nm and 283 nm in methanol.
  4. Viscosity (Brookfield): 240 cps at 25°C.
  5. pH (5% aqueous solution): 6.0 to 8.0.
  6. Critical micelle concentration (CMC): 0.22 to 0.24 mM.

• 용도

  Detergent, equivalent to Nonidet P-40.Triton X-100 is used as a non-ionic detergent, emulsifier and dispersing agent. It is useful for isolation of membrane proteins. It is also used in electrophoresis. It is an active ingredient in influenza vaccine (Fluzone). It finds applications in the dispersion of carbon materials for soft composite materials and restricting colony expansion in Aspergillus nidulans in microbiology. Further, it is an active ingredient in homemade vinyl record cleaning fluids together with distilled water and isopropyl alcohol.

• 정의

  ChEBI: A poly(ethylene glycol) terminated with a 4-(2,4,4-trimethylpentan-3-yl) phenyl group at one end.

• 일반 설명

  Triton X-305 is a non-ionic surfactant. This octylphenol ethoxylate has higher number of ethylene oxide units, increased cmc (Critical micelle concentration) and hydrophile/lipophile balance when compared to Triton X-100. Triton X-305 is compatible with anionic, cationic, and other nonionic surfactants and chemically stable in most acidic and alkaline solutions.
  Triton X-100 is a nonionic detergent, 100% active ingredient, which is often used in biochemical applications to solubilize proteins. Triton X-100 has no antimicrobial properties. It is considered a comparatively mild detergent, non-denaturing, and is reported in numerous references as a routinely added reagent. It does absorb in the ultraviolet region of the spectrum, however, so can interfere with protein quantitation. A number of polymeric resins have been used to remove X-100 from solution, including Amberlite hydrophobic XAD resins and Rezorian A161 cartridges. The "X" series of Triton detergents are produced from octylphenol polymerized with ethylene oxide. The number ("-100") relates only indirectly to the number of ethylene oxide units in the structure. X100 has an "average of 9.5" ethylene oxide units per molecule, with an average molecular weight of 625. In addition, lower and higher mole adducts will be present in lesser amounts, varying slightly within supplier's standard manufacturing conditions. No antioxidants are added by Sigma or the manufacturer, but commercial preparations of Triton X-100 have been found to contain peroxides up to 0.22% hydrogen peroxide (H2O2) equivalents. These impurities may interfere with biological reactions. Sigma offers X-100-PC and X-100R-PC as biological grade alternatives.

• 생물학적 활성

  Triton X-100 causes a change in the fluorescence characteristics of the Tritoln X-100 effectively ruptures chloroplasts and reduces the electron flow required for the Hill reaction at low concentrations. Treatment of pea root cell preparations with Tritoln X-100 and low-speed centrifugation resulted in a pellet containing a large amount of stromal material (including RNA polymerase and DNA polymerase activity, most of the DNA, about 30% of the RNA, and 50% of the protein)^[1-2].

• Safety Profile

  Moderately toxic by ingestion and intravenous routes. Experimental reproductive effects. Human mutation data reported. An eye and human skin irritant. Many glycol ethers cause dangerous human reproductive effects. When heated to decomposition it emits toxic fumes of NOx. A surfactant. See also GLYCOL ETHERS.

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