Moxifloxacin hydrochloride

한글명:Moxifloxacin hydrochloride

카스 번호186826-86-8

상품명:Moxifloxacin hydrochloride

CBNumberCB3191433

분자식C21H25ClFN3O4

포뮬러 무게437.8923032

MOL 파일186826-86-8.mol

화학적 성질

녹는점	Slightly yellow to yellow crystalline powder, mp 324-325°
알파	25D -256° (c = 0.5 in water)
끓는 점	636℃
RTECS 번호	VB1983750
인화점	>110°(230°F)
저장 조건	2-8°C
용해도	H2O: 용해성5mg/mL, 투명(따뜻한)
물리적 상태	가루
색상	흰색에서 베이지색
수용성	물에 거의 용해되지 않습니다. DMSO에 용해됨
BRN	8377447
InChIKey	IDIIJJHBXUESQI-DFIJPDEKSA-N
SMILES	N1(C2CC2)C2=C(C=C(F)C(N3C[C@]4([H])CCCN[C@]4([H])C3)=C2OC)C(=O)C(C(O)=O)=C1.[H]Cl \|&1:12,18,r\|
CAS 데이터베이스	186826-86-8(CAS DataBase Reference)

위험 및 안전 성명

WGK 독일

위험 등급

IRRITANT

NFPA 704:

	0
2		0

그림문자(GHS)

Moxifloxacin hydrochloride 화학적 특성, 용도, 생산

개요
Moxifioxacin hydrochlodde is one of the two new fluoroquinolonecarboxylic acid antibiotics introduced in 1999 for the treatment of respiratory tract infections such as community-acquired pneumonia, acute exacerbations of bronchitis or acute sinusitis. Moxifloxacin can be synthesized through a 12 step sequence from the classical 4-quinolone-3-carboxylic acid template. Some advantages of Moxifloxacin over Ciprofloxacin, another of Bayer's launched quinolones, have been shown, i.e. an enhanced activity against Gram-positive bacteria (Streptococcus pneumoniae, Clostndium pneumoniae), a favorable pharmacokinetic profile (good tissue penetration and plasma concentrations above MICs) and a lack of phototoxicity (UVA irradiation).
화학적 성질
Light yellow to yellow crystalline powder
용도
Moxifloxacin Hydrochloride is an antibacterial agent that inhibits the activities of Topo II (DNA gyrase) and topoisomerase IV.
정의
ChEBI: Moxifloxacin hydrochloride is a hydrochloride comprising equimolar amounts of moxifloxacin and hydrogen chloride. It has a role as an antibacterial drug. It contains a moxifloxacinium(1+).
일반 설명
Moxifloxacin Hydrochloride is an anti-infectious compound that belongs to the class of fluoroquinolone antibiotics. It is a well-known broad-spectrum antibiotic prescription medicine effective against a variety of Gram-positive and Gram-negative bacteria including the anaerobic type. It is an S,S-isomer with two chiral centers. It works by preventing the activity of various crucial enzymes involved in the replication, transcription, recombination, and repair of deoxyribonucleic acid in the bacteria such as DNA gyrase (topoisomerase II), topoisomerase IV. It finds its application in the treatment of various ocular and respiratory tract infections.

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