DL-Menthol

한글명:DL-Menthol

카스 번호1490-04-6

상품명:DL-Menthol

CBNumberCB1116410

분자식C10H20O

포뮬러 무게156.27

MOL 파일1490-04-6.mol

화학적 성질

녹는점	34-36 °C(lit.)
끓는 점	216 °C(lit.)
밀도	0.89 g/mL at 25 °C(lit.)
증기압	0.8 mm Hg ( 20 °C)
FEMA	2665 \| MENTHOL RACEMIC
인화점	200 °F
저장 조건	Sealed in dry,Room Temperature
용해도	Very soluble in ethanol (95%), chloroform, ether, fatty oils and liquid paraffin; freely soluble in glacial acetic acid;soluble in acetone and benzene; very slightly soluble in glycerin; practically insoluble in water.
산도 계수 (pKa)	15.30±0.60(Predicted)
색상	투명 무색
냄새	디프로필렌 글리콜 중 10.00%. 쿨링 멘톨릭 민트
?? ??	멘톨
JECFA Number	427
Dielectric constant	3.2（Ambient）
안정성	안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
InChIKey	NOOLISFMXDJSKH-UHFFFAOYSA-N
LogP	3.3-3.79 at 25℃
CAS 데이터베이스	1490-04-6(CAS DataBase Reference)
NIST	Menthol(1490-04-6)
EPA	Menthol (1490-04-6)

위험 및 안전 성명

위험품 표기	Xn,Xi
위험 카페고리 넘버	37/38-41-48/20/22-40-22
안전지침서	36/37/39-36-26
유엔번호(UN No.)	UN 1888 6.1/PG 3
WGK 독일	2
RTECS 번호	OT0525000
HS 번호	29061100
유해 물질 데이터	1490-04-6(Hazardous Substances Data)

그림문자(GHS)

DL-Menthol MSDS

DL-Menthol 화학적 특성, 용도, 생산

순도시험

(1) 응고점 : 이 품목의 응고점은 27～28℃이어야 한다.
  (2) 치몰 : 이 품목 0.2g을 빙초산 2mL, 황산 6방울 및 질산 2방울의 찬 혼액에 가할 때, 착색되어서는 아니 된다.
  (3) 비선광도 : 이 품목 약 2.5g을 정밀히 달아 에탄올에 녹여 25mL로 하여 이 액의 선광도를 측정할 때, ＝-2～+2°이어야 한다.
  (4) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
  (5) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.
확인시험

(1) 이 품목을 같은 양의 장뇌 또는 치몰과 저어 섞으면 액상이 된다.
(2) 이 품목 1g에 황산 20mL를 가하여 흔들어 섞으면 탁해져서 황색 비슷한 적색을 나타내나 24시간 후에는 멘톨의 향기가 없는 투명한 기름을 분리한다.
정량법

이 품목 약 1g을 정밀히 달아 향료시험법 중 알콜류함량측정법 제2법에 따라 시험한다.
0.5N 알콜성수산화칼륨용액 1mL = 78.13mg C₁₀H₂₀O
화학적 성질
Racemic menthol is a mixture of equal parts of the (1R,2S,5R)- and (1S,2R,5S)-isomers of menthol. It is a free-flowing or agglomerated crystalline powder, or colorless, prismatic, or acicular shiny crystals, or hexagonal or fused masses with a strong characteristic odor and taste. The crystalline form may change with time owing to sublimation within a closed vessel. The USP 32 specifies that menthol may be either naturally occurring l-menthol or syntheti-cally prepared racemic or dl-menthol. However, the JP XV and PhEur 6.0, along with other pharmacopeias, include two separate monographs for racemic and l-menthol.
용도
Labelled Menthol. Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.
정의
ChEBI: Any secondary alcohol that is one of the eight possible diastereoisomers of 5-methyl-2-(propan-2-yl)cyclohexan-1-ol.
생산 방법
Menthol occurs widely in nature as l-menthol and is the principal component of peppermint and cornmint oils obtained from the Mentha piperita and Mentha arvensis species. Commercially, lmenthol is mainly produced by extraction from these volatile oils. It may also be prepared by partial or total synthetic methods.
Racemic menthol is prepared synthetically via a number of routes, e.g. by hydrogenation of thymol.
Pharmaceutical Applications
Menthol is widely used in pharmaceuticals, confectionery, and toiletry products as a flavoring agent or odor enhancer. In addition to its characteristic peppermint flavor, l-menthol, which occurs naturally, also exerts a cooling or refreshing sensation that is exploited in many topical preparations. Unlike mannitol, which exerts a similar effect due to a negative heat of solution, l-menthol interacts directly with the body’s coldness receptors. d-Menthol has no cooling effect, while racemic menthol exerts an effect approximately half that of l-menthol.
When used to flavor tablets, menthol is generally dissolved in ethanol (95%) and sprayed onto tablet granules and not used as a solid excipient.
Menthol has been investigated as a skin-penetration enhancer and is also used in perfumery, tobacco products, chewing gum and as a therapeutic agent. When applied to the skin, menthol dilates the blood vessels, causing a sensation of coldness followed by an analgesic effect. It relieves itching and is used in creams, lotions, and ointments. When administered orally in small doses menthol has a carminative action.
Safety
Almost all toxicological data for menthol relate to its use as a therapeutic agent rather than as an excipient. Inhalation or ingestion of large quantities can result in serious adverse reactions such as ataxia and CNS depression,hypersensitivity reactions, severe abdominal pain, nausea, vomiting, vertigo, drowsiness, and coma.Although menthol is essentially nonirritant there have been some reports of hypersensitivity following topical application. In a Polish study approximately 1% of individuals were determined as being sensitive to menthol.There have been reports of apnea and instant collapse in infants after the local application of menthol to their nostrils.
The WHO has set an acceptable daily intake of menthol at up to 0.4 mg/kg body-weight.
LD₅₀ (rat, IM): 10.0 g/kg
LD₅₀ (rat, oral): 3.18 g/kg
저장
A formulation containing menthol 1% w/w in aqueous cream has been reported to be stable for up to 18 months when stored at room temperature.
Menthol should be stored in a well-closed container at a temperature not exceeding 25°C, since it sublimes readily.
비 호환성
Incompatible with: butylchloral hydrate; camphor; chloral hydrate; chromium trioxide; b-naphthol; phenol; potassium permanganate; pyrogallol; resorcinol; and thymol.
Regulatory Status
Included in the FDA Inactive Ingredients Database (dental preparations, inhalations, oral aerosols, capsules, solutions, suspensions, syrups, and tablets; also topical preparations). Included in nonparenteral medicines licensed in the UK. Accepted for use in foods and confectionery as a flavoring agent of natural origin. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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