멘톨

한글명:멘톨

카스 번호89-78-1

상품명:DL-Menthol

CBNumberCB7498497

분자식C10H20O

포뮬러 무게156.27

MOL 파일89-78-1.mol

동의어(한글)

멘톨

맨톨

디/엘-멘톨

화학적 성질

녹는점	34-36 °C(lit.)
끓는 점	216 °C(lit.)
알파	-2 º (c=10, EtOH)
밀도	0.89 g/mL at 25 °C(lit.)
증기압	0.8 mm Hg ( 20 °C)
굴절률	1.4615
FEMA	2665 \| MENTHOL RACEMIC
인화점	200 °F
저장 조건	Store below +30°C.
용해도	456mg/l
물리적 상태	결정질 고체
산도 계수 (pKa)	15.30±0.60(Predicted)
색상	무색~백색
냄새	디프로필렌 글리콜 중 10.00%. 페퍼민트 쿨 우디
?? ??	멘톨
수용성	불용성
Merck	14,5837
JECFA Number	427
BRN	3194263
LogP	3.4 at 37℃
CAS 데이터베이스	89-78-1(CAS DataBase Reference)
NIST	DL-Menthol(89-78-1)
EPA	(1R,2S,5R)-Menthol (89-78-1)

위험 및 안전 성명

위험품 표기

Xn,Xi

위험 카페고리 넘버

37/38-41-36/37/38

안전지침서

36/37/39-24/25-36-26-39

유엔번호(UN No.)

UN 1888 6.1/PG 3

WGK 독일

RTECS 번호

OT0350000

자연 발화 온도

405 °C

TSCA

Yes

HS 번호

29061100

독성

LD50 orally in rats: 3180 mg/kg (Jenner)

NFPA 704:

	1
2		0

그림문자(GHS)

멘톨 MSDS

멘톨 화학적 특성, 용도, 생산

물성
시원한 청량감을 주는 휘발성 성분으로서, 박하속(민트) 식물들에 다량 함유되어 있다. 특유의 청량감 때문에 향신료로 많이 사용되며, 사탕이나 음료 등에 첨가되기도 한다.
개요
녹는점 43℃, 끓는점 216.5℃이지만 상온에서 쉽게 승화한다. 육각형의 침상(針狀) 또는 프리즘 모양의 결정이다. 물에 약간 녹고 알코올에 녹는다. 멘톨의 제조법에서 천연물로서는 우선 박하유를 추출하고, 이것을 냉각하여 거친 결정으로 만들고 재결정하여 정제한다. 또한 합성할 때는 멘톤·프레곤·피페리톤·티몰·이소프레골 등 케톤의 수소첨가를 한다.
순도시험

(1) 융점 : 이 품목의 융점은 42～43℃이어야 한다.
  (2) 비선광도 : 이 품목 약 2.5g을 정밀히 달아 에탄올에 녹여 25mL로 하여 이 액의 선광도를 측정할 때, ＝-45～-51°이어야 한다.
  (3) 치몰 : 이 품목 0.2g을 빙초산 2mL, 황산 6방울 및 질산 2방울의 찬 혼액에 가할 때, 착색되어서는 아니 된다.
  (4) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
  (5) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.
확인시험

(1) 이 품목의 에탄올용액(1→10)은 좌선성이다.
(2) 「dl-멘톨」의 확인시험 (1) 및 (2)에 따라 시험한다.
정량법

이 품목 약 1g을 정밀히 달아 향료시험법 중 알콜류함량측정법 제2법에 따라 시험한다.
0.5N 알콜성수산화칼륨용액 1mL ＝ 78.13mg C₁₀H₂₀O
개요
Menthol has a mint-like odor and a fresh, cooling taste. It may be prepared by hydrogenation of thymol.
화학적 성질
colorless to white crystalline solid
물리적 성질
Appearance: colorless or white acicular prismatic crystals or white crystalline powder. Solubility: easily dissolved in ethanol, chloroform, ether, liquid paraffin, or volatile oil and soluble in water. Odor: a cool, refreshing, and pleasant mint aroma, sweet odor, and taste cool early after burning. Boiling point: 212?°C. Melting point: 41–43?°C. Specific optical rotation: ?49 to ?50°.
출처
Reported found in peppermint and other mint oils (e.g., M. arvensis), lemon peel oil, cranberry, pineapple, cab bage, thymus, egg, rum, cocoa, tea, honey, avocado, coriander, mango, rice, litchi, dill herb, calamus, juniper berries, fennel, buchu oil, clam and Roman chamomile oil, Mentha species.
역사
In the world of aromatic chemicals, menthol is often described as a unique source of skin and mucous membranes. Menthol is mainly extracted from natural plants. The vast majority of natural menthol in the global market is extracted from numerous Asian mint. In 2006, the world’s natural menthol production is 12,800?tons or more. However, due to various factors, the production of natural menthol is becoming less and less. Since the 1960s, Japan, Germany, and other countries had developed the synthetic menthol products. In 1974 the German company Symrise and Japan Takasago Fluidic Systems company launched chemical synthesis of menthol. At present, attention has been paid to the study of menthol analogy substances and the effect of the changes of molecular structure on the aroma and cool sensation. Some studies have shown that hydroxyl groups located in the branched or 1, 4 chain cannot show a sense of cool. The researchers believed that menthol analogy substances with optical activity should be able to show different, surprising cooling effect, and the structure of hydroxyl alkyl groups is the key point to have a cooling effect. The Japanese chemist Ryoji Noyo and his colleagues found that in BINAP and rhodium complexes as catalysts for asymmetric hydrogenation reaction, the synthesis of menthol is very effective. Because of the contribution of asymmetric organic synthesis, they won the 2001 Nobel Prize in Chemistry.
용도
DL-Menthol may be used as an extraction solvent for the determination of parabens in food products, cosmetics and pharmaceuticals using liquid-liquid microextraction with high performance liquid chromatography-diode array detection (HPLC-DAD). It may also be used for the preparation of hydrophobic deep eutectic solvent (DES) in the extraction and determination of methylparaben, propylparaben, and butylparaben from cosmetics samples using syringe-to-syringe dispersive magnetic nanofluid microextraction procedure (SS-DMNF-ME) with high-performance liquid chromatography technique (HPLC).
Indications
For external application, it is applied locally and often used to relieve pain and itching. A nasal drip is used in the head cold. Inhalation or spray is used for sore throat. Oral administration can promote digestion.
제조 방법
By hydrogenation of thymol.
일반 설명
White crystalline solid with a peppermint odor and taste.
공기와 물의 반응
Insoluble in water.
반응 프로필
DL-Menthol is incompatible with butyl chloral hydrate, camphor, phenol, chloral hydrate, Exalgine, betanaphthol, resorcinol or thymol in triturations; potassium permanganate, chromium trioxide and pyrogallol. DL-Menthol is also incompatible with strong oxidizers.
위험도
Irritant to mucous membranes on inhalation.
화재위험
DL-Menthol is combustible.
Clinical Use
It can be clinically used to assist anesthesia, postoperative analgesia, intercostal nerve block, trigeminal nerve block, occipital nerve block, and so on. When applied locally, it can promote blood circulation, diminish inflammation, relieve itching, relieve pain, relieve edema, and so on.
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. A severe eye irritant. Incompatible with phenol, p-naphthol, resorcinol or thymol in trituration, potassium permanganate, chromium trioxide, pyrogallol. Combustible liquid. \When heated to decomposition it emits acrid smoke and irritating fumes.

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