계피산

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H302：삼키면 유해함

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

계피산 화학적 특성, 용도, 생산

• 순도시험

    (1) 융점 : 이 품목의 융점은 132～135℃이어야 한다.

    (2) 용상 : 이 품목 1g을 에탄올 7mL에 녹일 때, 그 액은 징명하여야 한다.

    (3) 알칼리용상 : 이 품목 0.2g에 탄산나트륨시액 2mL 및 물 8mL를 넣어 녹일 때, 이 액은 징명하여야 한다.

    (4) 염소화합물 : 이 품목은 향료시험법 중 할로겐시험법의 동망법에 따라 시험할 때, 이에 적합하여야 한다.

    (5) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

    (6) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.

• 확인시험

    (1) 이 품목 0.5g에 황산 1mL를 넣어 수욕 중에서 가열하여 녹일 때, 그 액은 황록색을 나타내며 계속 가열하면 암적색으로 변한다.

    (2) 이 품목 0.1g을 수산화칼륨시액 2mL에 녹인 다음 과망간산칼륨시액 5mL를 넣어 온탕 중에서 가온하면 벤즈알데히드 향기를 발생한다.

• 정량법

    이 품목을 건조한 다음 0.2g을 정밀히 달아 중화알콜 10mL 및 물 10mL를 가해 녹이고 0.1N 수산화나트륨용액으로 적정한다(지시약 : 페놀프탈레인시액 3방울).

  0.1N 수산화나트륨용액 1mL ＝ 14.816mg C₉H₈O₂

• 강열잔류물

    이 품목의 강열잔류물은 0.05% 이하이어야 한다.

• 개요

  Cinnamic acid is a white crystalline organic acid, which is slightly soluble in water.
  It is obtained from oil of cinnamon, or from balsams such as storax. It is also found in shea butter and is the best indication of its environmental history and post-extraction conditions. It can also be made synthetically.
  Cinnamic acid is used in flavors, synthetic indigo, and certain pharmaceuticals, though its primary use is in the manufacturing of the methyl, ethyl, and benzyl esters for the perfume industry. Cinnamic acid has a honey- like odor; it and its more volatile ethyl ester (ethyl cinnamate) are flavor components in the essential oil of cinnamon, in which related cinnamaldehyde is the major constituent. Cinnamic acid is also part of the biosynthetic shikimate and phenyl propanoid pathways. Its biosynthesis is performed by action of the enzyme phenylalanine ammonia - lyase (PAL) on phenylalanine.
  Cinnamic acid is freely soluble in benzene, diethyl ether, acetone, and it is insoluble in hexane.
  Cinnamic acid is also a kind of self-inhibitor produced by fungal spore to prevent germination.

• 화학적 성질

  Cinnamic acid is almost odorless with a burning taste, and then turning sweet and reminiscent of apricot.

• 출처

  The trans- form has been found among the constituents of the essential oils of basil, Chinese cinnamon, Melaleuca bracteata, Alpinia galanga. It is reported found in Peru balsam, Asian and American storax and cocoa leaves. Also reported found in strawberry fruit, beer, cognac, starfruit (Averrhoa carambola L) and loquat. The cis- form is present in the oil of Alpinia malacensis.

• 용도

  cinnamic acid has sunscreen capabilities. Some manufacturers use it to replace PABA because of its lower allergic and phototoxic reaction incidence. Cinnamic acid is found in cinnamon leaves and cocoa leaves, and is an essential oil of certain mushrooms. It may cause allergic skin rashes.

• 정의

  ChEBI: A monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. It is found in Cinnamomum cassia.

• 제조 방법

  Two isomers, trans- and cis- exist; the trans-isomer is of interest for use in flavoring; in addition to the extraction from natural sources (storax), it can be prepared as follows: (1) from benzaldehyde, anhydrous sodium acetate and acetic anhydride in the presence of pyridine (Perkin reaction); (2) from benzaldehyde and ethyl acetate (Claisen condensation); (3) from benzaldehyde and acetylene chloride; (4) by oxidation of benzylidene acetone with sodium hypochlorite.

• Safety Profile

  Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. A skin irritant. Combustible liquid. When heated to decomposition it emits acrid smoke and fumes.

• Purification Methods

  Crystallise the acid from *benzene, CCl4, hot water, water/EtOH (3:1), or 20% aqueous EtOH. Dry it at 60o in vacuo. It is steam volatile. [Beilstein 9 IV 2002.]

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