ブレオマイシン硫酸塩 (混合物)

化学名:ブレオマイシン硫酸塩 (混合物)

CAS番号.9041-93-4

英語名:Bleomycin sulfate

CBNumberCB8412175

MFC110H168N34O46S7

MW2927.17

别名

硫酸ブレオマイシン

ブレオマイシン硫酸塩 (混合物)

硫酸ブレオマイシン (混合物)

ブレオマイシン硫酸塩 (混合物)物理性質

融点	200-204°C (dec.)
貯蔵温度	2-8°C
溶解性	H₂O: 20 mg/mL
外見	粉
色	白い
水溶解度	水またはDMSOに可溶
Merck	14,1318
安定性：	-20°C の蒸留水で最長 3 か月間保存できます。
InChIKey	OOXTWFJZZAJGKA-YWZNXBAZNA-N
CAS データベース	9041-93-4(CAS DataBase Reference)

安全性情報

危険有害性情報のコード(GHS)

外観
白色～黄赤色～緑色粉末～結晶
効能
抗生物質, 抗悪性腫瘍薬
商品名
ブレオS (日本化薬)
化学的特性
White Powder
使用
Bleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding to oxygen and a metal ion, such as copper or iron. Able to cleave RNA, but at less and more selective degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.
一般的な説明
Bleomycin occurs as a white powder and is available in 15-and 30-U vials for reconstitution in water. It may be givenintravenously, intramuscularly, or subcutaneously. It is used in the treatment of squamous cell carcinoma of the headneck, cervix, penis, and vulva. It is also used in Hodgkin’sand non-Hodgkin’s lymphoma as well as testicular carcinoma.Unlabeled uses include the treatment of mycosis fungoides,osteosarcoma, and AIDS-related Kaposi sarcoma.
臨床応用
Bleomycin is used IV in the palliative treatment of squamous cell head and neck cancers, testicular and other genital carcinomas, and Hodgkin's and non-Hodgkin's lymphoma.
副作用
It is excreted via the kidneys, and serum concentrations of active drug are increased in patients with renal disease. The elimination half-life can rise from 2 to 4 hours to more than 20 hours in renal failure, resulting in significant toxicity, especially pulmonary toxicity.