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D-マンニトール

D-マンニトール 化学構造式
69-65-8
  • CAS番号.69-65-8
  • 化学名:D-マンニトール
  • 别名:D-マンニトール;D-マンニット;(2R,3R,4R,5R)-1,2,3,4,5,6-ヘキサンヘキサオール;マンナ糖;マンニトール;ジオスモル;マニトン;マンニットT;マンニデクス;オスミトール;マニコール;D-manno-ヘキシトール;コルジセプ酸;オスモサル;マンニットール;マニトール;マンニゲン;D-マンニトル;D(-)-マンニトール;Dマンニトル
  • 英語化学名:D-Mannitol
  • 英語别名:Manna;Mannit;Isotol;SDM-25;Sugari;Manita;invenex;Osmosal;MANNITE;Diosmol
  • CBNumber:CB7720972
  • Molecular Formula:C6H14O6
  • Formula Weight:182.17
  • MOL File:69-65-8.mol
D-マンニトール 物理性質
  • 融点  :167-170 °C(lit.)
  • 沸点  :295°C
  • 比旋光度  :141 º (c= USP-directives)
  • 比重(密度)  :1.52
  • 屈折率  :1.3330 (estimate)
  • 闪点  :290-295°C/3.5mm
  • 貯蔵温度  :2-8°C
  • 溶解性 :H2O: 1 M at 20 °C, clear, colorless
  • 外見  :Crystalline Powder
  • 酸解離定数(Pka) :13.5(at 18℃)
  • 色 :White
  • PH :5.0-6.5 (25℃, 1M in H2O)
  • 光学活性 (optical activity) :[α]25/D +23.3 to +24.3°(lit.)
  • 水溶解度  :soluble
  • 極大吸収波長 (λmax) :λ: 260 nm Amax: 0.04
    λ: 280 nm Amax: 0.04
  • Merck  :14,5745
  • BRN  :1721898
  • 安定性: :Stable. Combustible. Incompatible with strong oxidizing agents.
  • InChIKey :FBPFZTCFMRRESA-KVTDHHQDSA-N
  • CAS データベース :69-65-8(CAS DataBase Reference)
  • NISTの化学物質情報 :D-Mannitol(69-65-8)
  • EPAの化学物質情報 :D-Mannitol (69-65-8)
安全性情報
  • 主な危険性  :Xi
  • Rフレーズ  :36/37/38
  • Sフレーズ  :24/25-36-26
  • WGK Germany  :2
  • RTECS 番号 :OP2060000
  • F  :3
  • 自然発火温度 :410 °C
  • TSCA  :Yes
  • HSコード  :29054300
  • 有毒物質データの :69-65-8(Hazardous Substances Data)
  • 毒性 :LD50 orally in Rabbit: 13500 mg/kg
D-マンニトール 価格 もっと(86)
  • メーカー: 富士フイルム和光純薬株式会社(wako)
  • 製品番号: W01CHDASB-00013102
  • 製品説明 : マンニトール, D-
  • 純度: Mannitol, D-
  • 包装: 250mg
  • 価格: ¥10900
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 富士フイルム和光純薬株式会社(wako)
  • 製品番号: W01CHDASB-00013102
  • 製品説明 : マンニトール, D-
  • 純度: Mannitol, D-
  • 包装: 1g
  • 価格: ¥18300
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 東京化成工業
  • 製品番号: M0044
  • 製品説明 : D-マンニトール
  • 純度: D-Mannitol >99.0%(T)
  • 包装: 25g
  • 価格: ¥1600
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 東京化成工業
  • 製品番号: M0044
  • 製品説明 : D-マンニトール
  • 純度: D-Mannitol >99.0%(T)
  • 包装: 500g
  • 価格: ¥4400
  • 更新時間: 2021/03/23
  • 購入: 購入
  • メーカー: 関東化学株式会社(KANTO)
  • 製品番号: 25085-01
  • 製品説明 : D(-)‐マンニトール
  • 純度: D(-)‐Mannitol>99.0%(T)
  • 包装: 500g
  • 価格: ¥2800
  • 更新時間: 2021/03/23
  • 購入: 購入

D-マンニトール MSDS


D-Mannitol

D-Mannitol 化学特性,用途語,生産方法

  • 外観 白色, 結晶~結晶性粉末
  • 定義 本品は、次の化学式で表される糖アルコールである。
  • 溶解性 水に溶けやすく、エタノールにやや溶けにくく、ジエチルエーテルにほとんど溶けない。
  • 解説 マンニトールmannitolともいい、糖アルコールの一種で、マンノースのアルデヒド基が還元されて六価アルコールとなった構造をもつ。分子式はC6H14O6で、分子量は182。水に溶けて甘味があり、還元性はない。無色の結晶で、融点は166℃。天然にもっとも多い糖アルコールで、海藻、菌類、マンナトネリコやタマネギなど植物に広く分布する。ある種のカビや乳酸菌は、グルコースやフルクトースからマンニット発酵で多量に生成する。医薬用の希釈剤や賦形剤などの用途がある。[池田加代子] "D-マンニットの構造式
    小学館 日本大百科全書(ニッポニカ) )
  • 用途 医薬品原料、分析試薬、糖類研究用。
  • 化粧品の成分用途 保湿.湿潤剤、保水剤、結合剤、香味剤
  • 効能 降圧薬 (脳圧, 眼圧), 診断補助薬 (腎機能判定), 利尿薬
  • 商品名 マンニット (テルモ); マンニットール (陽進堂)
  • 説明 A white, crystalline solid consisting of D-mannitol and a small quantity of sorbitol. It is odorless and has a sweet taste. It is soluble in water, very slightly soluble in alcohol, and practically insoluble in most other common organic solvents. It is prepared commercially by catalytic reduction of glucose. Mannitol occurs in small amounts in a variety of foods such as olives, beets, and celery, and in the exudate of certain trees.
  • 化学的特性 White or almost white, crystalline powder or free-flowing granules.
  • 化学的特性 Mannitol is D-mannitol. It is a hexahydric alcohol related to mannose and is isomeric with sorbitol.
    Mannitol occurs as a white, odorless, crystalline powder, or freeflowing granules. It has a sweet taste, approximately as sweet as glucose and half as sweet as sucrose, and imparts a cooling sensation in the mouth. Microscopically, it appears as orthorhombic needles when crystallized from alcohol. Mannitol shows polymorphism.
  • Originator Mannitol,MSD,US,1946
  • 使用 inhibitor of norepinephrine and seritonin uptake, treatment of fibromyalgia
  • 使用 Labelled D-Mannitol (M165000). D-Mannitol is widespread in plants and plant exudates; obtained from manna and seaweeds. D-Mannitol is used in the food industry as anticaking and free-flow agent, flavo ring agent, lubricant and release agent, stabilizer and thickener and nutritive sweetener.
  • 使用 Used in titrimetric determination of boric acid.
  • 使用 Used with boric acid in the manufacture of dry electrolytic condensers for radio applications; in making artificial resins and plasticizers; in pharmacy as excipient and diluent for solids and liqs; in analytical chemistry for boron determinations; in the manufacture of mannitol hexanitrate. Used in the food industry as anticaking and free-flow agent, flavoring agent, lubricant and release agent, stabilizer and thickener and nutritive sweetener.
  • 定義 ChEBI: The D-enantiomer of mannitol.
  • 調製方法 Mannitol may be extracted from the dried sap of manna and other natural sources by means of hot alcohol or other selective solvents. It is commercially produced by the catalytic or electrolytic reduction of monosaccharides such as mannose and glucose.
  • Manufacturing Process 250 g of glucose is dissolved in distilled water to give a solution of 48% concentration. This solution is heated to 65°C and barium hydroxide added in quantity sufficient to make the concentration of the barium hydroxide 0.2 mol/liter. The solution is agitated and maintained at 65°C for 6 hours after the addition of the barium hydroxide. It is then cooled and neutralized to a pH of 6.8 with sulfuric acid. The precipitated barium sulfate is filtered out. A quantity of activated supported nickel catalyst containing 5 g of nickel is added.
    The slurry is introduced into a 3-liter rocking autoclave, and hydrogen admitted to a pressure of 1,500 psi. The autoclave is heated to a temperature of 150°C in one hour and held at this temperature for 2.5 hours more. Pressure rises to about 1,800 psi and then declines to about 1,600 during the hydrogenation. The autoclave is then cooled, emptied, and the catalyst filtered from the product. The filtrate is then concentrated under vacuum on a hot water bath to remove a part of the water.
    The concentrate is taken up in warm aqueous methanol so adjusted that the composition of the solvent is 90% methanol/10% water, and the weight of the solvent is 3 times the weight of the solids in the concentrate. This solution is cooled to 20°C and held overnight. The mannitol which crystallizes is filtered out. The filtrate is concentrated on a water bath under vacuum to remove methanol and adjusted to a water percentage of 16%. The resulting syrup is viscous, noncrystallizing and nongelling, and analysis shows a PN (Pyridine Number) of 32 and essentially no reducing sugar, according to US Patent 2,749,371.
  • brand name Osmitrol (Baxter Healthcare); Resectisol (B Braun).
  • Therapeutic Function Diuretic, Diagnostic aid (kidney function)
  • 一般的な説明 Odorless white crystalline powder or free-flowing granules. Sweet taste.
  • 空気と水の反応 Water soluble.
  • 反応プロフィール A sugar alcohol. More closely related to carbohydrates than to other polyhydric alcohols [Noller]. Flammable and/or toxic gases are generated by the combination with alkali metals, nitrides, strong reducing agents and strong oxidizing agents.
  • 危険性 Mildly toxic; mutagen.
  • 火災危険 D-Mannitol is probably combustible.
  • 応用例(製薬) Mannitol is widely used in pharmaceutical formulations and food products. In pharmaceutical preparations it is primarily used as a diluent (10–90% w/w) in tablet formulations, where it is of particular value since it is not hygroscopic and may thus be used with moisture-sensitive active ingredients.
    Mannitol may be used in direct-compression tablet applications,for which the granular and spray-dried forms are available, or in wet granulations.Granulations containing mannitol have the advantage of being dried easily. Specific tablet applications include antacid preparations, glyceryl trinitrate tablets, and vitamin preparations. Mannitol is commonly used as an excipient in the manufacture of chewable tablet formulations because of its negative heat of solution, sweetness, and ‘mouth feel’.
    In lyophilized preparations, mannitol (20–90% w/w) has been included as a carrier to produce a stiff, homogeneous cake that improves the appearance of the lyophilized plug in a vial.A pyrogen-free form is available specifically for this use. Mannitol has also been used to prevent thickening in aqueous antacid suspensions of aluminum hydroxide (<7% w/v). It has been suggested as a plasticizer in soft-gelatin capsules, as a component of sustained-release tablet formulations,and as a carrier in dry powder inhalers.It is also used as a diluent in rapidly dispersing oral dosage forms.It is used in food applications as a bulking agent. Therapeutically, mannitol administered parenterally is used as an osmotic diuretic, as a diagnostic agent for kidney function, as an adjunct in the treatment of acute renal failure, and as an agent to reduce intracranial pressure, treat cerebral edema, and reduce intraocular pressure. Given orally, mannitol is not absorbed significantly from the gastrointestinal tract, but in large doses it can cause osmotic diarrhea;
  • Biochem/physiol Actions A sugar alcohol sweet tastant. Used in sweetness inhibition studies.
  • 安全性 Mannitol is a naturally occurring sugar alcohol found in animals and plants; it is present in small quantities in almost all vegetables. Laxative effects may occur if mannitol is consumed orally in large quantities.If it is used in foods as a bodying agent and daily ingestion of over 20g is foreseeable, the product label should bear the statement ‘excessive consumption may have a laxative effect’. After intravenous injection, mannitol is not metabolized to any appreciable extent and is minimally reabsorbed by the renal tubule, about 80% of a dose being excreted in the urine in 3 hours.
    A number of adverse reactions to mannitol have been reported, primarily following the therapeutic use of 20% w/v aqueous intravenous infusions.The quantity of mannitol used as an excipient is considerably less than that used therapeutically and is consequently associated with a lower incidence of adverse reactions. However, allergic, hypersensitive-type reactions may occur when mannitol is used as an excipient.
    An acceptable daily intake of mannitol has not been specified by the WHO since the amount consumed as a sweetening agent was not considered to represent a hazard to health.
    LD50 (mouse, IP): 14 g/kg
    LD50 (mouse, IV): 7.47 g/kg
    LD50 (mouse, oral): 22 g/kg
    LD50 (rat, IV): 9.69 g/kg
    LD50 (rat, oral): 13.5 g/kg
  • 貯蔵 Mannitol is stable in the dry state and in aqueous solutions. Solutions may be sterilized by filtration or by autoclaving and if necessary may be autoclaved repeatedly with no adverse physical or chemical effects.In solution, mannitol is not attacked by cold, dilute acids or alkalis, nor by atmospheric oxygen in the absence of catalysts. Mannitol does not undergo Maillard reactions.
    The bulk material should be stored in a well-closed container in a cool, dry place.
  • 純化方法 D-Mannitol is crystallised from EtOH, MeOH or H2O and dried at 100o. [Thomson Acta Chem Scand 6 270, 279, 280 1952, Beilstein 1 IV 2841.]
  • 不和合性 Mannitol solutions, 20% w/v or stronger, may be salted out by potassium chloride or sodium chloride.Precipitation has been reported to occur when a 25% w/v mannitol solution was allowed to contact plastic.Sodium cephapirin at 2 mg/mL and 30 mg/mL concentration is incompatible with 20% w/v aqueous mannitol solution. Mannitol is incompatible with xylitol infusion and may form complexes with some metals such as aluminum, copper, and iron. Reducing sugar impurities in mannitol have been implicated in the oxidative degradation of a peptide in a lyophilized formation.Mannitol was found to reduce the oral bioavailability of cimetidine compared to sucrose.
  • 規制状況(Regulatory Status) GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IP, IM, IV, and SC injections; infusions; buccal, oral and sublingual tablets, powders and capsules; ophthalmic preparations; topical solutions). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Mon-medicinal Ingredients.
D-マンニトール 上流と下流の製品情報
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D-マンニトール 生産企業
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69-65-8, D-マンニトール キーワード:
  • 69-65-8
  • D-Mannitol tested according to Ph.Eur.
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  • D-マンニトール
  • D-マンニット
  • (2R,3R,4R,5R)-1,2,3,4,5,6-ヘキサンヘキサオール
  • マンナ糖
  • マンニトール
  • ジオスモル
  • マニトン
  • マンニットT
  • マンニデクス
  • オスミトール
  • マニコール
  • D-manno-ヘキシトール
  • コルジセプ酸
  • オスモサル
  • マンニットール
  • マニトール
  • マンニゲン
  • D-マンニトル
  • D(-)-マンニトール
  • Dマンニトル
  • D(-)‐マンニトール
  • マンニット D-(-)-マンニトール
  • マンニット
  • マンニトール, D-
  • マンニトール, analytical grade
  • D-マンニトール (JP17)
  • マンノース
  • 生化学
  • 糖アルコール
  • 甘味料
  • 降圧薬
  • 浸透圧性利尿薬
  • 利尿薬
  • 食品添加物