1,2-ジブロモエタン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

  H350：発がんのおそれ

  H411：長期的影響により水生生物に毒性

• 注意書き

  P273：環境への放出を避けること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P310：飲み込んだ場合：直ちに医師に連絡すること。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

1,2-ジブロモエタン 価格

MSDS Information

• EDB

1,2-ジブロモエタン 化学特性,用途語,生産方法

• 外観

  無色澄明の液体

• 溶解性

  水に難溶 (0.4g/100ml水), アルコール, エーテル等各種有機溶剤に易溶。エタノール及びアセトンに極めて溶けやすく、水にほとんど溶けない。

• 解説

  1,2-ジブロモエタン,融点9.5 ℃，沸点132 ℃．d⁰2.21．加水分解するとエチレングリコールが，アンモニアを作用させるとエチレンジアミンが，シアン化カリウムと反応させてスクシノニトリルCNCH2CH2CNがそれぞれ得られる．線虫の防除に広く用いられている．
  森北出版「化学辞典（第2版)

• 用途

  線虫の防除に広く用いられている1,2-ジブロモエタン．

• 製造

  1,2-ジブロモエタン：BrCH2CH2Br．臭化エチレンともいう．エチレンに臭素を付加させるか，アセチレンに臭化水素を付加させると得られる．

• 化学的特性

  1,2-Dibromoethane is a colorless nonflammable liquid with a mild sweet odor, like chloroform. The minimum concentration detectable by odor is 10 ppm.It is stable at room temperature, but can be slowly decomposed into toxic substances under light. It is miscible with ethanol, ether, carbon tetrachloride, benzene, gasoline and other organic solvents, and forms azeotropes, and dissolves in about 250 times of water. Noncombustible. Very toxic by inhalation, skin absorption or ingestion. used as a solvent, scavenger for lead in gasoline, grain fumigant and in the manufacture of other chemicals.

• 物理的性質

  Colorless liquid with a sweet, chloroform-like odor. Odor threshold concentration is 25 ppb (quoted, Keith and Walters, 1992).

• 使用

  1,2-Dibromoethane (EDB) is used as a fumigant for grains, in antiknock gasolines, as asolvent, and in organic synthesis. Most of the uses of 1,2-dibromoethane have been stopped in the United States; however, it is still used as a fumigant for treatment of logs for termites and beetles, for the control of moths and beehives, and as a preparation for dyes and waxes.

• 定義

  ChEBI: 1,2-dibromoethane is a bromoalkane that is ethane carrying bromo substituents at positions 1 and 2. It is produced by marine algae. It has a role as a fumigant, a carcinogenic agent, a marine metabolite, an algal metabolite, a mouse metabolite and a mutagen. It is a bromohydrocarbon and a bromoalkane.

• 製造方法

  1,2-Dibromoethane is manufactured via uncatalyzed, liquid-phase bromination of ethylene. Gaseous ethylene is brought into contact with bromine by various methods, allowing for dissipation of the heat of the reaction.

• 一般的な説明

  1,2-dibromomethane is a heavy, colourless liquid with a mild sweet odour, like chloroform. Ethylene dibromide is incompatible with strong oxidisers, magnesium, alkali metals, and liquid ammonia. Ethylene dibromide is soluble in alcohols, ethers, acetone, benzene, and most organic solvents and slightly soluble in water. It reacts with lead residues to generate volatile lead bromides. Because of limitations in epidemiological study evidences for ethylene dibromide as a human carcinogen is inconclusive. In 1984, the U.S. EPA imposed a ban on its use as a soil and grain fumigant.

• 空気と水の反応

  Slightly soluble in water. May react slowly with moisture.

• 反応プロフィール

  1,2-Dibromoethane slowly decomposes in the presence of light and heat. Turns brown upon exposure to light. Corrosive to iron and other metals. May decompose upon contact with alkalis. Incompatible with oxidizing agents. Reacts with sodium, potassium, calcium, powdered aluminum, zinc, magnesium and liquid ammonia. May attack some plastics, rubber and coatings. May poison platinum catalysts [Hawley]. Reacts as an alkylating agent .

• 危険性

  Probable carcinogen. Toxic by inhalation, ingestion, and skin absorption; strong irritant to eyes and skin.

• 健康ハザード

  1,2-Dibromoethane is toxic by inhalation,ingestion, or skin contact. The acute toxicsymptoms are depression of the central ner vous system, irritation and congestion oflungs, hepatitis, and renal damage. Chronicexposure can produce conjunctivitis, bron chial irritation, headache, depression, lossof appetite, and loss of weight. Recoveryoccurs after cessation of exposure. Prolongedor repeated exposures to high concentrationscan be fatal to animals and humans. Lethalconcentration for a 2-hour exposure period is400 ppm in rats.
  1,2-Dibromoethane is moderate to highlytoxic by ingestion. Its toxicity is far greaterthan that of 1,2-dichloroethane. An oralintake of 5 to 10 mL of the liquid can be fatalto humans. Death occurs from necrosis of theliver and kidney damage. The oral LD50 val ues varied between 50 and 125 mg/kg fordifferent species of laboratory animals.
  Vapors are irritant to the eyes. Contactwith the liquid can damage vision. Skincontact may produce severe irritation andblistering.
  Mutagenic tests were positive, while thehistidine reversion–Ames test gave incon clusive results (NIOSH 1986). 1,2-Dibromo ethane is carcinogenic to animals and issuspected to cause cancer in humans. Inhala tion of this compound produced tumors inthe lungs and nose in mice and rats. Oraladministration caused cancers in the liver andgastrointestinal tract.

• 燃焼性と爆発性

  Ethylene dibromide is a noncombustible substance (NFPA rating = 0).

• 农业用途

  Fumigant, Nematicide: Not approved for use in EU countries. Not registered for use in the U.S. Persons whose clothing or skin is contaminated with liquid ethylene dibromide (above 10°C) can secondarily contaminate others by direct contact or through off-gassing vapor. Ethylene dibromide was used extensively as a pesticide and an ingredient of soil, vegetable, fruit, and grain fumigant formulations. Still used in India, South Africa and other countries. There are 15 global suppliers.

• 製品名

  AADIBROOM®; EDB-85; FUMO-GAS®; ISCOBROME D®; KOPFUME®; NEFIS®; NEPHIS®; SOILFUME®; UNIFUME®

• 安全性プロファイル

  Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and teratogenic data. Human poison by ingestion. Experimental poison by ingestion, sktn contact, intraperitoneal, and possibly other routes. Moderately toxic by inhalation and rectal routes. Human systemic effects by ingestion: hypermothty, barrhea, nausea or vomiting, decreased urine volume or anuria. Experimental reproductive effects. Human mutation data reported. A severe skin and eye irritant. Implicated in worker sterdity. When heated to decomposition it emits toxic fumes of Br-. See also ETHYLENE DICHLORIDE and BROMIDES.

• 職業ばく露

  Ethylene dibromide is used as a chemical intermediate; as a fumigant for ground pest control; as a constituent of ethyl gasoline (anti-knock agent). It is also used in fire extinguishers, gauge fluids, and waterproofing preparations; and it is used as a solvent for celluloid, fats, oils, and waxes. Pesticide not in use; TRI and/or IUR indicates importers or manufacturers are unlikely

• 発がん性

  1,2-Dibromoethane is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
  Cancer Studies in Experimental Animals

• 代謝経路

  The bacterial strain GP1 can utilize 1,2-dibromoethane as a sole carbon and energy source. The first step in 1,2-dibromoethane is catalyzed by a hydrolytic haloalkane dehalogenase and the resulting 2- bromoethanol is rapidly converted to ethylene oxide, preventing the accumulation of 2-bromoethanol and 2- bromoacetaldehyde. However, the further metabolic pathway(s) is unclear.

• 貯蔵

  work with EDB should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and safety goggles should be worn to prevent skin contact. Gloves and protective clothing should be changed immediately if EDB contamination occurs. Since EDB can penetrate neoprene and other plastics, protective apparel made of these materials does not provide adequate protection from contact with EDB.

• 輸送方法

  UN1605/154 Ethylene dibromide, Hazard Class: 6.1; Labels: 6.1-Poison Inhalation Hazard, Inhalation Hazard Zone B

• 純化方法

  Wash the dibromide with conc HCl or H2SO4, then water, aqueous NaHCO3 or Na2CO3, more water, and dry it with CaCl2. Fractionally distil it. Alternatively, keep in daylight with excess bromine for 2hours, then extract with aqueous Na2SO3, wash with water, dry with CaCl2, filter and distil. It can also be purified by fractional crystallisation by partial freezing. Store it in the dark. [Beilstein 1 H 90, 1 I 28, 1 II 61, 1 III 182, 1 IV 158.]

• 不和合性

  Reacts vigorously with chemically active metals; liquid ammonia, strong bases; strong oxidizers; causing fire and explosion hazard. Light, heat, and moisture can cause slow decomposition, forming hydrogen bromide. Attacks fats, rubber, some plastics and coatings.

• 廃棄物の処理

  Controlled incineration with adequate scrubbing and ash disposal facilities

1,2-ジブロモエタン 上流と下流の製品情報

1,2-ジブロモエタン 生産企業

Global(441)Suppliers

1,2-ジブロモエタン スペクトルデータ(¹HNMR、¹³CNMR、IR1、IR2、MS、Raman)

106-93-4, 1,2-ジブロモエタン キーワード