4-[2-ヒドロキシ-3-(イソプロピルアミノ)プロポキシ]ベンゼンプロパン酸メチル

4-[2-ヒドロキシ-3-(イソプロピルアミノ)プロポキシ]ベンゼンプロパン酸メチル 価格

4-[2-ヒドロキシ-3-(イソプロピルアミノ)プロポキシ]ベンゼンプロパン酸メチル 化学特性,用途語,生産方法

• 使用

  Esmolol is a cardioselective beta1 receptor blocking agent.

• 危険性

  A reproductive hazard.

• 臨床応用

  Esmolol (Brevibloc) is a short-acting intravenously administered β1-selective adrenoceptor blocking agent. It does not possess membrane-stabilizing activity or sympathomimetic activity.
  Esmolol is used in the treatment of supraventricular tachyarrhythmias for rapid control of ventricular rate and reduction of myocardial oxygen consumption. Discontinuation of administration is followed by a rapid reversal of its pharmacological effects because of esmolol’s rapid hydrolysis by plasma esterases.

• 副作用

  The most frequently reported adverse effects are hypotension, nausea, dizziness, headache, and dyspnea.As with many β-blocking drugs, esmolol is contraindicated in patients with overt heart failure and those in cardiogenic shock.

• 代謝

  The -blocker esmolol (Brevibloc) is unusual in that it is very rapidly metabolized; its plasma half-life is only 9 minutes. It is subject to hydrolysis by cytosolic esterases in red blood cells to yield methanol and an acid metabolite, the latter having an elimination half-life of about 4 hours. Only 2% of the administered esmolol is excreted unchanged. Because of its rapid onset and short duration of action, esmolol is used by the intravenous route for the control of ventricular arrhythmias in emergencies.

4-[2-ヒドロキシ-3-(イソプロピルアミノ)プロポキシ]ベンゼンプロパン酸メチル 上流と下流の製品情報

4-[2-ヒドロキシ-3-(イソプロピルアミノ)プロポキシ]ベンゼンプロパン酸メチル 生産企業

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