酢酸ナファレリン

酢酸ナファレリン 価格

酢酸ナファレリン 化学特性,用途語,生産方法

• 外観

  白色～うすい黄色, 結晶～粉末

• 溶解性

  水に可溶

• 用途

  ゴナドトロピン放出ホルモン （Gn-RH）誘導体です。Gn-RH 受容体との親 和性を高めた化合物であり、生物活性が増強 し、持続的作用を示します。

• 効能

  子宮内膜症治療薬, 性腺刺激ホルモン放出ホルモン受容体作動薬

• 商品名

  ナサニール (ファイザー)

• 説明

  Nafarelin acetate is a synthetic decapeptide agonist analog of the natural gonadotropin-releasing hormone, differing in the amino acid at position 6 where D-naphthylalanine has been substituted for glycine. This substitution gives nafarelin greater potency and a substantially longer half-life than the endogenous hormone. Nafarelin acetate administered as a nasal spray, suppresses estrogen levels on repeated dosing and is indicated for the management of endometriosis. It also has orphan drug status for use in precocious puberty.

• 使用

  Nafarelin Acetate is a gonadotropin-releasing hormone agonist. Treatment with Nafarelin improves sleep disturbances and anxiety-depression. Nafarelin is also used in the treatment of estrogen-dependent gynecologic disorders such as endometriosis and uterine leiomyomas.

• 臨床応用

  Nafarelin acetate, contains D Nal(2)6 [Nal = 3-(2-naphthyl)-Ala] in place of Gly6, but the C-terminus, Gly10-NH2, is identical with natural GnRH. Nafarelin acetate is available as a 0.2% nasal spray for the relief of endometriosis. Estrogen, of course, is needed for the growth of endometrial tissue; thus, decreased estrogen leads to shrinkage of errant endometrial tissue. The observed side effects of nafarelin acetate are related to falling estrogen levels and include decreased libido, amenorrhea, hot flashes, and vaginal dryness. When used consistently, nafarelin acetate will inhibit ovulation and stop menstruation.
  Nafarelin acetate also is used in children, male and female, for the treatment of central precocious puberty. By suppressing the release of LH, the estradiol or testosterone levels fall to prepubertal levels; early secondary sexual development is arrested, linear growth and skeletal maturation are slowed, and in girls, menstruation stops.

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86220-42-0, 酢酸ナファレリン キーワード