N-(tert-ブトキシカルボニル)-L-プロリン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

N-(tert-ブトキシカルボニル)-L-プロリン 価格

MSDS Information

• (S)-1,2-Pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) ester

N-(tert-ブトキシカルボニル)-L-プロリン 化学特性,用途語,生産方法

• 外観

  白色～ほとんど白色、結晶～結晶性粉末

• 説明

  N-Boc-L-proline is a synthetic intermediate. It has been used in the synthesis of enantioselective catalysts for aldol reactions and hepatitis C virus (HCV) NS5A inhibitors.

• 化学的特性

  White to off-white microcrystalline powder

• 使用

  N-Boc-L-proline is used as an intermediate in organic synthesis. It is also used to prepare daclatasvir, which inhibits the hepatitis C virus (HCV) non-structural 5A (NS5A) protein. Further, it is used as a drug in the treatment of hepatitis C virus (HCV).

• 製造方法

  Triethylamine (16.5 mL, 0.12 mmol) was added dropwise over a period of 10 min to a stirred, ice-cold suspension of l-proline (10.0 g, 8.7 mmol) in dichloromethane (200 mL) in a 500-mL three-necked, round-bottomed flask. A solution of Boc2O (28.3 g, 0.13 mmol) in dichloromethane (100 mL) was then added over a period of 10 min and the mixture was stirred for 2.5 h. Thereafter, 10% aqueous citric acid (50 mL) was added, and the dichloromethane layer was washed with saturated brine (2×50 mL) and with water (50 mL). After drying the organic phase over magnesium sulfate, the solvent was evaporated and the residue was taken up in hot ethyl acetate. Dilution of this solution with hexane gave the product, N-tertbutoxycarbonyl- L-proline (17.8 g, 95%); mp 138–140℃; TLC (silica gel): Rf=0:36 (EtOAc/MeOH, 1:1).

N-(tert-ブトキシカルボニル)-L-プロリン 上流と下流の製品情報

N-(tert-ブトキシカルボニル)-L-プロリン 生産企業

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N-(tert-ブトキシカルボニル)-L-プロリン スペクトルデータ(¹HNMR、IR1、IR2、MS、Raman)

15761-39-4, N-(tert-ブトキシカルボニル)-L-プロリン キーワード