セトロレリクス

化学名:セトロレリクス

CAS番号.120287-85-6

英語名:Cetrorelix

CBNumberCB0316370

MFC70H92ClN17O14

MW1431.04

MOL File120287-85-6.mol

别名

セトロレリックス

セトロレリクス

N-アセチル-3-(2-ナフタレニル)-D-Ala-4-クロロ-D-Phe-3-(3-ピリジル)-D-Ala-L-Ser-L-Tyr-N5-(アミノカルボニル)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2

セトロレリクス物理性質

融点	>259°C (dec.)
比重(密度)	1.42±0.1 g/cm3(Predicted)
貯蔵温度	Refrigerator
溶解性	DMSO（微量、加温）、メタノール（微量）
外見	個体
酸解離定数(Pka)	9.82±0.15(Predicted)
色	ホワイトからオフホワイト
InChIKey	SBNPWPIBESPSIF-MHWMIDJBSA-N

安全性情報

有毒物質データの

120287-85-6(Hazardous Substances Data)

危険有害性情報のコード(GHS)

セトロレリクス化学特性,用途語,生産方法

効能
性腺刺激ホルモン放出ホルモン受容体拮抗薬
説明
Cetrorelix was launched in Germany for the treatment of female infertility. It is a decapeptidic analog of luteinizing hormone-releasing hormone (LH-RH) bearing structural modifications in the crucial positions 1, 2, 3, 6 and 10 : [Ac-D-Nal1, D-4-CI Phe-2, D-Pal3, D-Cit6, D-Alal0]-GnRH. Cetrorelix is an extremely potent and long acting gonadotrophin releasing hormone (GnRH) antagonist and thus blocks gonadotrophins and sex steroid secretion immediately after administration. Moreover, it has a low histamine-releasing potency. Cetrorelix will be the first LH-RH antagonist approved worldwide. In several Phase III clinical trials, female patients receiving Cetrorelix had a successful controlled ovulation thus avoiding a premature LH-surge. Cetrorelix could be a first-choice in-vitro fertilization (IVF) treatment without the complications of current controlled ovarian hyperstimulation protocols. Cetrorelix is currently under clinical investigation for the treatment of diverse sex hormone dependent disorders such as benign prostate hypertrophy, breast, ovarian or prostate cancers and diverse gynaecological disorders.
定義
ChEBI: Cetrorelix is a synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-tyrosyl, N(5)-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast. It has a role as a GnRH antagonist and an antineoplastic agent.
適応症
Cetrorelix is used to delay your ovaries from releasing eggs too early (ovulation). It is indicated for the inhibition of premature LH surges in women undergoing controlled ovarian stimulation.

セトロレリクス上流と下流の製品情報

セトロレリクス生産企業

セトロレリクススペクトルデータ(MS)

120287-85-6, セトロレリクスキーワード

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セトロレリクス

危険有害性情報のコード(GHS)

セトロレリクス 化学特性,用途語,生産方法

セトロレリクス 上流と下流の製品情報

セトロレリクス 生産企業

セトロレリクス スペクトルデータ(MS)

120287-85-6, セトロレリクス キーワード

セトロレリクス化学特性,用途語,生産方法

セトロレリクス上流と下流の製品情報

セトロレリクス生産企業

セトロレリクススペクトルデータ(MS)

120287-85-6, セトロレリクスキーワード