アンギオテンシン(ヒト型)

アンギオテンシン(ヒト型) 価格

アンギオテンシン(ヒト型) 化学特性,用途語,生産方法

• 外観

  凍結乾燥品

• 溶解性

  水に溶ける。エタノール及びアセトンにほとんど溶けない。

• 用途

  薬理・生理研究試薬、高血圧の研究。

• 用途

  薬理・生理研究試薬。

• 効能

  昇圧薬, 血管収縮薬, アンジオテンシンII受容体作動薬

• 説明

  It is known that tumor tissues including metastatic lymph nodes are composed of newly growing vessels which lack blood flow autoregulation and are influenced only secondarily by the responding somatic vessels. Human angiotensin II (AT II). a vasopressor, was introduced in Japan to improve the efficacy of systemic chemotherapy. In patients with various advanced cancers, i.v. infusion of AT II to achieve a mean blood pressure of 1.5 times of baseline (but not over 150 mm Hg) followed by a bolus injection of conventional cytotoxic agents increases blood flow 5-7 fold in tumor tissues and therefore, increases drug delivery to the target tissue resulting in enhanced chemotherapeutic effects. This induced-hypertension chemotherapy regimen can be performed safely with minimal side effects.

• 使用

  Cardiopulmonary resuscitation - not yet an approved application

• 一般的な説明

  Functions in blood pressure maintenance. Stimulates the release of aldosterone from the adrenal gland. Has strong vasoconstrictive effects. Increases the entry of Ca²⁺ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase. Activates JAK2 in smooth muscle cells. Activates p125^FAK and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. Also activates pp60c-src in vascular smooth muscle cells. Inhibits adenylate cyclase activity in spontaneously hypertensive rats.

• 概要

  血管収縮性ホルモン．転換酵素の作用でアンジオテンシンⅠより生じる．Ile→Val (ウシ)．アンジオテンシンⅢ：ⅡのN末端Aspが除去されたもの

アンギオテンシン(ヒト型) 上流と下流の製品情報

アンギオテンシン(ヒト型) 生産企業

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アンギオテンシン(ヒト型) スペクトルデータ(¹HNMR、MS)

4474-91-3, アンギオテンシン(ヒト型) キーワード