酢酸トリプトレリン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H360：生殖能または胎児への悪影響のおそれ

酢酸トリプトレリン 価格

酢酸トリプトレリン 化学特性,用途語,生産方法

• 効能

  抗悪性腫瘍薬, 性腺刺激ホルモン放出ホルモン受容体作動薬

• 説明

  Triptorelin acetate (TA) is a GnRH agonist that was earlier used as a veterinary drug for a single fixed-time artificial insemination through the synchronised estrous cycle of weaned sows. The risk assessment was that the Food Safety Commission of Japan (FSCJ) concluded that TA is not likely to cause adverse effects on human health through dietary exposure. Because TA does not have genotoxicity relevant to human health and is degraded in the digestive tract, its oral bioavailability is low. TA is currently used for the treatment of central precocious puberty and assisted reproduction. Injectable TA alone or in combination with levonorgestrel intrauterine device is also used to treat endometrial atypical hyperplasia (EAH) . Combination therapy is more effective, improving patients' menstrual abnormalities, endometrial thickening and quality of life, and is safe.

• 化学的特性

  White Solid

• 使用

  Synthetic peptide agonist analog of LH-RH. Triptorelin acetate is a potent agonist of LH-releasing hormone, currently used in the treatment of prostatic cancer where therapy may be required over months or years. Antineoplastic (hormonal). Used in the treatment of endometriosis and infertility.

• 副作用

  Triptorelin acetate has been reported to have a possible side effect of severe bone loss. The first report was of an 8-year-old girl with central precocious puberty who experienced anaphylactic shock after the first injection of decapeptide containing triptorelin acetate (D,L lactide coglycolide), dextran 70, and polysorbate 80. However, it is also possible that it was a reaction to the polysorbate. Therefore, doctors should be aware of immediate reactions to drugs containing polysorbates.

酢酸トリプトレリン 生産企業

Global(162)Suppliers

140194-24-7, 酢酸トリプトレリン キーワード