rac-(2R*)-プロパン-1,2,3-トリオール1-[(9Z)-9-オクタデセノアート]

化学名:rac-(2R*)-プロパン-1,2,3-トリオール1-[(9Z)-9-オクタデセノアート]

CAS番号.25496-72-4

英語名:MONOOLEIN

CBNumberCB5757259

MFC21H40O4

MW356.54

MOL File25496-72-4.mol

别名

rac-オレイン酸(2R*)-2,3-ジヒドロキシプロピル

rac-(2R*)-グリセリン1-オレアート

1-O-オレイル-rac-グリセロール

rac-(2R*)-プロパン-1,2,3-トリオール1-[(9Z)-9-オクタデセノアート]物理性質

融点	35-37 °C
沸点	449.35°C (rough estimate)
比重(密度)	0.96 g/cm³ (25 ºC)
屈折率	1.4626 (589.3 nm 40℃)
FEMA	2526 \| GLYCERYL MONOOLEATE
貯蔵温度	−20°C
溶解性	クロロホルム：50 mg/mL 無色透明
水溶解度	<3.57mg/L(30℃)
安定性：	Hygroscopic
CAS データベース	25496-72-4(CAS DataBase Reference)
EPAの化学物質情報	Glyceryl monooleate (25496-72-4)

安全性情報

WGK Germany	1
F	3
HSコード	3822000002
有毒物質データの	25496-72-4(Hazardous Substances Data)

危険有害性情報のコード(GHS)

rac-(2R*)-プロパン-1,2,3-トリオール1-[(9Z)-9-オクタデセノアート] 価格

製品番号	包装	価格	製品説明	購入
富士フイルム和光純薬株式会社(wako) W01USP1295753	500mg	￥101800	モノオレイン酸グリセリル 40%	購入
Sigma-Aldrich Japan G0400007	g0400007	￥24800	European Pharmacopoeia (EP) Reference Standard	購入
Sigma-Aldrich Japan 1295742	250mg	￥60100	90%, United States Pharmacopeia (USP) Reference Standard	購入
Sigma-Aldrich Japan G0400007		￥35200	European Pharmacopoeia (EP) Reference Standard	購入

rac-(2R*)-プロパン-1,2,3-トリオール1-[(9Z)-9-オクタデセノアート] 化学特性,用途語,生産方法

定義
本品は、オレイン酸(*)とグリセリン(*)のモノエステルであり、次の化学式で表される。
参照表示名称：オレイン酸, グリセリン
化粧品の成分用途
エモリエント剤、乳化剤、香料
説明
§ 184.1323(a) Glyceryl monooleate is prepared by esterification of commercial oleic acid that is derived either from edible sources or from tall oil fatty acids meeting the requirements of §172.862. It contains glyceryl monooleate (C21H40O4 and glyceryl esters of fatty acids present in commercial oleic acid.
化学的特性
Colourless Solid
使用
93% 1-Oleoyl, 7% 2-oleoyl
定義
An antifog agent and dispersant.
調製方法
Glyceryl monooleate is prepared by the esterification of glycerol with fatty acids, chiefly oleic acid. As the fatty acids are not pure substances, but rather a mixture of fatty acids, the product obtained from the esterification will contain a mixture of esters, including stearic and palmitic. Di- and triesters may also be present. The composition and, therefore, the physical properties of glyceryl monooleate may thus vary considerably from manufacturer to manufacturer; e.g. the melting point may vary from 10–35°C.
応用例（製薬）
Glyceryl monooleate is a polar lipid that swells in water to give several phases with different rheological properties. It is available in both nonemulsifying (n/e) and self-emulsifying (s/e) grades, the self-emulsifying grade containing about 5% of an anionic surfactant.
The nonemulsifying grade is used in topical formulations as an emollient and as an emulsifying agent for water-in-oil emulsions. It is also a stabilizer for oil-in-water emulsions. The self-emulsifying grade is used as a primary emulsifier for oil-in-water systems.
Glyceryl monooleate gels in excess water, forming a highly ordered cubic phase that can be used to sustain the release of various water-soluble drugs.It is also the basis of mucoadhesive drug delivery systems.
Glyceryl monooleate is reported to enhance transdermal and buccal penetration.
安全性プロファイル
When heated to decomposition it emits acrid smoke and irritating fumes.
安全性
Glyceryl monooleate is used in oral and topical pharmaceutical formulations and is generally regarded as a relatively nonirritant and nontoxic excipient.
貯蔵
Glyceryl monooleate should be stored in an airtight container, protected from light in a cool, dry place.
不和合性
Glyceryl monooleate is incompatible with strong oxidizing agents. The self-emulsifying grade is incompatible with cationic surfactants.
規制状況(Regulatory Status)
GRAS listed. Included in the FDA Inactive Ingredients Database (oral capsules, oral powder, oral tablets; creams, controlled-release transdermal films). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

rac-(2R*)-プロパン-1,2,3-トリオール1-[(9Z)-9-オクタデセノアート] 生産企業

25496-72-4, rac-(2R*)-プロパン-1,2,3-トリオール1-[(9Z)-9-オクタデセノアート] キーワード

Send Inquriy